000 03326nam a22004935i 4500
001 978-0-387-26283-3
003 DE-He213
005 20161121230634.0
007 cr nn 008mamaa
008 100301s2006 xxu| s |||| 0|eng d
020 _a9780387262833
_9978-0-387-26283-3
024 7 _a10.1007/b137303
_2doi
050 4 _aRC254-282
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a616.994
_223
245 1 4 _aThe Link Between Inflammation and Cancer
_h[electronic resource] :
_bWounds that do not heal /
_cedited by Angus G. Dalgleish, Burkhard Haefner.
264 1 _aBoston, MA :
_bSpringer US,
_c2006.
300 _aXII, 254 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Treatment and Research,
_x0927-3042 ;
_v130
505 0 _aInflammation and Cancer -- Chronic Inflammation and Pathogenesis of GI and Pancreatic Cancers -- Cytokines, NF-?B, Microenvironment, Intestinal Inflammation and Cancer -- Regulation if NF-?B Transcriptional Activity -- The Role of Immune Cells in the Tumor Microenvironment -- Tumor-Microenvironment Interactions -- CD95L/FasL and TRAIL in Tumour Surveillance and Cancer Therapy -- Infection & Neoplastic Growth 101 -- Cytokines as Mediators and Targets for Cancer Cachexia -- Targeting NF-?B in Anticancer Adjunctive Chemotherapy.
520 _aThe transcription factor NF-kB has long been known to play a central role in the immune system by regulating the expression of key genes. Moreover, activation of this transcription factor helps a wide variety of cell types survive damage induced by pro-apoptotic stimuli. Owing to its critical role in the regulation of pro-inflammatory genes, NF-kB has long been regarded as a promising target for the discovery of anti-inflammatory drugs. More recently, NF-kB has emerged as a major culprit in a variety of human cancers mainly due to its ability to protect transformed cells from apoptosis. This finding should not have come as a surprise since there exists a link between inflammation and many types of cancer which was already suggested by Galen and later demonstrated by Virchow. This link, of crucial importance for the design of novel strategies for cancer treatment, is the topic of this book. Series Editor Cover Comments: "Inflammation is a known risk factor for a number of cancers. In this text, experts discuss the pathophysiology and molecular alterations that link these two processes. Potential therapeutics and preventive strategies are discussed." Steven T. Rosen, M.D. Series Editor.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aLaboratory medicine.
650 0 _aOncology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aOncology.
650 2 4 _aCancer Research.
650 2 4 _aLaboratory Medicine.
700 1 _aDalgleish, Angus G.
_eeditor.
700 1 _aHaefner, Burkhard.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387262826
830 0 _aCancer Treatment and Research,
_x0927-3042 ;
_v130
856 4 0 _uhttp://dx.doi.org/10.1007/b137303
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c501735
_d501735