000 03750nam a22005655i 4500
001 978-3-540-26811-6
003 DE-He213
005 20161121230558.0
007 cr nn 008mamaa
008 100301s2005 gw | s |||| 0|eng d
020 _a9783540268116
_9978-3-540-26811-6
024 7 _a10.1007/b138119
_2doi
050 4 _aRS400-431
072 7 _aPSB
_2bicssc
072 7 _aSCI013020
_2bisacsh
082 0 4 _a615.19
_223
245 1 0 _aAnimal Models of T Cell-Mediated Skin Diseases
_h[electronic resource] /
_cedited by T. Zollner, H. Renz, K. Asadullah.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2005.
300 _aXIII, 291 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aErnst Schering Research Foundation Workshop,
_x0947-6075 ;
_v50
505 0 _aMaking Gene-Modified Mice -- High-Throughput Gene Knockouts and Phenotyping in Mice -- Modelling Gene-Environment Interactions in Th1- and Th2-Dominated Diseases of Laboratory Animals -- Animal Models of Experimental Asthma -- Models of Rheumatoid Arthritis -- Animal Models of Inflammatory Bowel Diseases -- Murine Models of Atopic Dermatitis -- Epicutaneous Sensitization with Allergens as an Atopic Dermatitis Model -- T-Cell Receptor Transgenic Models of Inflammatory Disorders: Relevance for Atopic Dermatitis? -- What Must a Model Display for Proof as a Model of Psoriasis? -- From Classical Mouse Models of Psoriasis to a Spontaneous Xenograft Model Featuring Use of AGR Mice -- The Psoriasis SCID Mouse Model: A Tool for Drug Discovery? -- Pro- and Anti-inflammatory Effects of IL-4: From Studies in Mice to Therapy of Autoimmune Diseases in Humans -- What Must a Model Display for Proof as a Model of Contact Dermatitis? -- Acute and Chronic Models of Allergic Contact Dermatitis: Advantages and Limitations -- Transgenic Mice Expressing IFN-? in the Epidermis Are a Model of Inflammatory Skin Disease and Systemic Lupus Erythematosus.
520 _aPharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.
650 0 _aChemistry.
650 0 _aMedicinal chemistry.
650 0 _aDermatology.
650 0 _aInternal medicine.
650 0 _aRespiratory organs
_xDiseases.
650 0 _aCell biology.
650 1 4 _aChemistry.
650 2 4 _aMedicinal Chemistry.
650 2 4 _aDermatology.
650 2 4 _aBiomedicine general.
650 2 4 _aCell Biology.
650 2 4 _aPneumology/Respiratory System.
650 2 4 _aInternal Medicine.
700 1 _aZollner, T.
_eeditor.
700 1 _aRenz, H.
_eeditor.
700 1 _aAsadullah, K.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540210672
830 0 _aErnst Schering Research Foundation Workshop,
_x0947-6075 ;
_v50
856 4 0 _uhttp://dx.doi.org/10.1007/b138119
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c500860
_d500860