000 03345nam a22005295i 4500
001 978-1-84628-016-0
003 DE-He213
005 20161121230556.0
007 cr nn 008mamaa
008 100301s2005 xxk| s |||| 0|eng d
020 _a9781846280160
_9978-1-84628-016-0
024 7 _a10.1007/b136184
_2doi
050 4 _aRC927-927.5
072 7 _aMJM
_2bicssc
072 7 _aMED083000
_2bisacsh
082 0 4 _a616.723
_223
245 1 0 _aBone Resorption
_h[electronic resource] /
_cedited by Felix Bronner, Mary C Farach-Carson, Janet Rubin.
264 1 _aLondon :
_bSpringer London,
_c2005.
300 _aXIV, 190 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aTopics in Bone Biology ;
_v2
505 0 _aOsteoclast: Origin and Differentiation -- Osteolytic Enzymes of Osteoclasts -- Regulation of Osteoclast Activity -- Structural Aspects of Bone Resorption -- Inflammatory Cytokines -- Genetics and Mutations Affecting Osteoclast Development and Function -- Clinical Disorders Associated with Alterations in Bone Resorption -- Pharmaceuticals for Bone Disease Targeting the Osteoclast -- Skeletal Complications of Malignancy: Central Role for the Osteoclast.
520 _aBone Resorption, the second volume in the series Topics in Bone Biology, deals with the osteoclast, the bone-resorbing cell, its origins, its enzymes, the regulation of osteoclast activity, and structural aspects of bone resorption. Diseases involving osteoclast function are discussed from the genetic viewpoint in two chapters that span transgenic mouse models to human pathology. Another chapter treats diseases of osteoclast function. Because osteoporosis may be considered a disease in which the bone resorption rate exceeds formation, a separate chapter deals with current and potential therapeutic approaches to this widespread disease that affects both men and women. Bone metastases and an analysis of the central role of the osteoclast in this condition are treated in the concluding chapter. The reviews in the book are essential reading for clinicians, researchers and students in a variety of fields: skeletal biology and orthopedics, nutrition, rheumatology, endocrinology, nephrology, oncology, dentistry, nursing, and chiropractic medicine. Together with the earlier volume on Bone Formation, this volumes serves as a beacon to a field that has become a major topic for those who study the health concerns of the aged, the very young, athletes and those with cancer.
650 0 _aMedicine.
650 0 _aInternal medicine.
650 0 _aEndocrinology.
650 0 _aRheumatology.
650 0 _aOrthopedics.
650 1 4 _aMedicine & Public Health.
650 2 4 _aRheumatology.
650 2 4 _aOrthopedics.
650 2 4 _aInternal Medicine.
650 2 4 _aEndocrinology.
700 1 _aBronner, Felix.
_eeditor.
700 1 _aFarach-Carson, Mary C.
_eeditor.
700 1 _aRubin, Janet.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781852338121
830 0 _aTopics in Bone Biology ;
_v2
856 4 0 _uhttp://dx.doi.org/10.1007/b136184
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c500804
_d500804