000 | 03345nam a22005295i 4500 | ||
---|---|---|---|
001 | 978-1-84628-016-0 | ||
003 | DE-He213 | ||
005 | 20161121230556.0 | ||
007 | cr nn 008mamaa | ||
008 | 100301s2005 xxk| s |||| 0|eng d | ||
020 |
_a9781846280160 _9978-1-84628-016-0 |
||
024 | 7 |
_a10.1007/b136184 _2doi |
|
050 | 4 | _aRC927-927.5 | |
072 | 7 |
_aMJM _2bicssc |
|
072 | 7 |
_aMED083000 _2bisacsh |
|
082 | 0 | 4 |
_a616.723 _223 |
245 | 1 | 0 |
_aBone Resorption _h[electronic resource] / _cedited by Felix Bronner, Mary C Farach-Carson, Janet Rubin. |
264 | 1 |
_aLondon : _bSpringer London, _c2005. |
|
300 |
_aXIV, 190 p. _bonline resource. |
||
336 |
_atext _btxt _2rdacontent |
||
337 |
_acomputer _bc _2rdamedia |
||
338 |
_aonline resource _bcr _2rdacarrier |
||
347 |
_atext file _bPDF _2rda |
||
490 | 1 |
_aTopics in Bone Biology ; _v2 |
|
505 | 0 | _aOsteoclast: Origin and Differentiation -- Osteolytic Enzymes of Osteoclasts -- Regulation of Osteoclast Activity -- Structural Aspects of Bone Resorption -- Inflammatory Cytokines -- Genetics and Mutations Affecting Osteoclast Development and Function -- Clinical Disorders Associated with Alterations in Bone Resorption -- Pharmaceuticals for Bone Disease Targeting the Osteoclast -- Skeletal Complications of Malignancy: Central Role for the Osteoclast. | |
520 | _aBone Resorption, the second volume in the series Topics in Bone Biology, deals with the osteoclast, the bone-resorbing cell, its origins, its enzymes, the regulation of osteoclast activity, and structural aspects of bone resorption. Diseases involving osteoclast function are discussed from the genetic viewpoint in two chapters that span transgenic mouse models to human pathology. Another chapter treats diseases of osteoclast function. Because osteoporosis may be considered a disease in which the bone resorption rate exceeds formation, a separate chapter deals with current and potential therapeutic approaches to this widespread disease that affects both men and women. Bone metastases and an analysis of the central role of the osteoclast in this condition are treated in the concluding chapter. The reviews in the book are essential reading for clinicians, researchers and students in a variety of fields: skeletal biology and orthopedics, nutrition, rheumatology, endocrinology, nephrology, oncology, dentistry, nursing, and chiropractic medicine. Together with the earlier volume on Bone Formation, this volumes serves as a beacon to a field that has become a major topic for those who study the health concerns of the aged, the very young, athletes and those with cancer. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aInternal medicine. | |
650 | 0 | _aEndocrinology. | |
650 | 0 | _aRheumatology. | |
650 | 0 | _aOrthopedics. | |
650 | 1 | 4 | _aMedicine & Public Health. |
650 | 2 | 4 | _aRheumatology. |
650 | 2 | 4 | _aOrthopedics. |
650 | 2 | 4 | _aInternal Medicine. |
650 | 2 | 4 | _aEndocrinology. |
700 | 1 |
_aBronner, Felix. _eeditor. |
|
700 | 1 |
_aFarach-Carson, Mary C. _eeditor. |
|
700 | 1 |
_aRubin, Janet. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781852338121 |
830 | 0 |
_aTopics in Bone Biology ; _v2 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/b136184 |
912 | _aZDB-2-SME | ||
950 | _aMedicine (Springer-11650) | ||
999 |
_c500804 _d500804 |