000 04251nam a22004095i 4500
001 978-1-59259-976-9
003 DE-He213
005 20161121230556.0
007 cr nn 008mamaa
008 100301s2005 xxu| s |||| 0|eng d
020 _a9781592599769
_9978-1-59259-976-9
024 7 _a10.1007/978-1-59259-976-9
_2doi
050 4 _aRS1-441
072 7 _aMQP
_2bicssc
072 7 _aMED072000
_2bisacsh
082 0 4 _a615.1
_223
245 1 0 _aNatural Products
_h[electronic resource] :
_bDrug Discovery and Therapeutic Medicine /
_cedited by Lixin Zhang, Arnold L. Demain.
264 1 _aTotowa, NJ :
_bHumana Press,
_c2005.
300 _bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aFundamental Issues Related to Natural Product-Based Drug Delivery -- Natural Products and Drug Discovery -- Strategies -- Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products -- Automated Analyses of HPLC Profiles of Microbial Extracts -- Manipulating Microbial Metabolites for Drug Discovery and Production -- Improving Drug Discovery From Microorganisms -- Developments in Strain Improvement Technology -- Specific Groups of Drugs -- The Discovery of Anticancer Drugs From Natural Sources -- Case Studies in Natural-Product Optimization -- Terpenoids As Therapeutic Drugs and Pharmaceutical Agents -- Challenges and Opportunities in the Chinese Herbal Drug Industry -- Arsenic Trioxide and Leukemia -- Microbial Diversity -- New Methods to Access Microbial Diversity for Small Molecule Discovery -- Accessing the Genomes of Uncultivated Microbes for Novel Natural Products -- Specific Sources -- New Natural-Product Diversity From Marine Actinomycetes -- Novel Natural Products From Rainforest Endophytes -- Biological, Economic, Ecological, and Legal Aspects of Harvesting Traditional Medicine in Ecuador.
520 _aAlthough the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious. State-of-the-art and forward looking, Natural Products: Drug Discovery and Therapeutic Medicine will inspire industrial and academic researchers, practitioners, and developers to once again explore natural products as key sources for the many new drugs needed to solve still unmet medical needs.
650 0 _aPharmacy.
650 1 4 _aPharmacy.
650 2 4 _aPharmacy.
700 1 _aZhang, Lixin.
_eeditor.
700 1 _aDemain, Arnold L.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781588293831
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-59259-976-9
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c500800
_d500800