000			03502nam a22004455i 4500
001			978-1-59259-917-2
003			DE-He213
005			20161121230555.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9781592599172 _9978-1-59259-917-2
024	7		_a10.1007/978-1-59259-917-2 _2doi
050		4	_aRC681-688.2
072		7	_aMJD _2bicssc
072		7	_aMED010000 _2bisacsh
082	0	4	_a616.12 _223
245	1	0	_aPlatelet Function _h[electronic resource] : _bAssessment, Diagnosis, and Treatment / _cedited by Martin Quinn, Desmond Fitzgerald.
264		1	_aTotowa, NJ : _bHumana Press, _c2005.
300			_aXII, 398 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aContemporary Cardiology
505	0		_aPlatelet Physiology -- Platelet Physiology -- Platelet Integrins and Signaling -- Platelet Adhesion -- Structure-Function of the Platelet Cytoskeleton -- Platelets and Inflammation -- Platelet Signal-Dependent Protein Synthesis -- Phosphoproteomics of Human Platelets -- Assessing Platelet Function -- Platelet Function Studies -- Platelet Function Under Flow -- Pharmacodynamics of GPIIb-IIIa Receptor Blockade -- Prostanoid Generation in Platelet Function -- Platelets and Prothrombin -- Markers of Platelet Activation and Granule Secretion -- Genomic and Proteomic Analysis of Platelets -- Clinical Applications -- Antiplatelet Agents -- Assessing Platelet Function in Clinical Trials.
520			_aPlatelet function, or clot formation, is difficult to assess, but extremely important because inadvertent or excessive platelet activation underlies many common cardiovascular disorders, such as myocardial infarction, unstable angina, and stroke. In Platelet Function: Assessment, Diagnosis, and Treatment, a panel of leading researchers and clinicians review the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed. Comprehensive and state of the art, Platelet Function: Assessment, Diagnosis, and Treatment offers vascular researchers and clinicians a sound foundation for understanding platelet biology, assessing thrombotic risk in patients, and determining the rational dosing of antiplatelet agents.
650		0	_aMedicine.
650		0	_aCardiology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aCardiology.
700	1		_aQuinn, Martin. _eeditor.
700	1		_aFitzgerald, Desmond. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588292445
830		0	_aContemporary Cardiology
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-59259-917-2
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c500788 _d500788