000 03583nam a22004095i 4500
001 978-1-59259-909-7
003 DE-He213
005 20161121230555.0
007 cr nn 008mamaa
008 100301s2005 xxu| s |||| 0|eng d
020 _a9781592599097
_9978-1-59259-909-7
024 7 _a10.1007/978-1-59259-909-7
_2doi
050 4 _aRD598.5-598.7
072 7 _aMNJ
_2bicssc
072 7 _aMED085050
_2bisacsh
082 0 4 _a617.413
_223
245 1 0 _aCell Signaling in Vascular Inflammation
_h[electronic resource] /
_cedited by Jahar Bhattacharya.
264 1 _aTotowa, NJ :
_bHumana Press,
_c2005.
300 _aXII, 222 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aHeme Oxygenase-1 and Carbon Monoxide in Vascular Regulation -- Tumor Necrosis Factor-?/Receptor Signaling Through the Akt Kinase -- Protein Modifications by Nitric Oxide and Reactive Nitrogen Species -- Redox Signaling in Hypoxic Pulmonary Vasoconstriction -- cGMP-Dependent Protein Kinase in Regulation of the Perinatal Pulmonary Circulation -- Glutamate Receptor Activation in the Pathogenesis of Acute Lung Injury -- Carboxyl Methylation of Small GTPases and Endothelial Cell Function -- Pressure-Induced Inflammatory Signaling in Lung Endothelial Cells -- Regulation of Endothelial Barrier Function -- Sphingolipid Signaling -- Regulation of Cytokine Signaling -- Cell Signaling by Vasoactive Agents -- Reactive Oxygen Species and Cell Signaling in Lung Ischemia -- Pulmonary Vascular Barrier Regulation by Thrombin and Edg Receptors -- Second-Messenger Signaling in Lung Capillaries -- Plasma Membrane-to-Nucleus Calcium Signaling -- Signaling by Mitochondria -- Pro-Inflammatory Signaling by Endothelial Focal Complexes in Lung -- Hydrogen Peroxide As Intracellular Messenger -- Calcium-Inhibited Adenylyl Cyclase (AC6) Controls Endothelial Cell Barrier Function.
520 _aAlthough inflammatory disease of the vascular bed of the lung is a major cause of morbidity and mortality in both adult and pediatric age groups, the importance of vascular biology to its understanding, and in developing novel therapeutics, has been overlooked. In Cell Signaling in Vascular Inflammation, leading basic and clinical researchers review the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement. Authoritative and state-of-the-art, Cell Signaling in Vascular Inflammation offers physiologists, molecular and cell biologists, and pharmaceutical scientists a comprehensive survey of the signal transduction pathways in lung vascular cells that illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.
650 0 _aMedicine.
650 0 _aVascular surgery.
650 1 4 _aMedicine & Public Health.
650 2 4 _aVascular Surgery.
700 1 _aBhattacharya, Jahar.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781588295255
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-59259-909-7
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c500784
_d500784