000 03473nam a22004335i 4500
001 978-0-387-27545-1
003 DE-He213
005 20161121230553.0
007 cr nn 008mamaa
008 100301s2005 xxu| s |||| 0|eng d
020 _a9780387275451
_9978-0-387-27545-1
024 7 _a10.1007/0-387-27545-2
_2doi
050 4 _aRC254-282
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a616.994
_223
245 1 0 _aTumor Immunology and Cancer Vaccines
_h[electronic resource] /
_cedited by Samir N. Khleif.
264 1 _aBoston, MA :
_bSpringer US,
_c2005.
300 _aX, 398 p. 100 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Treatment and Research,
_x0927-3042 ;
_v123
505 0 _aBasic Tumor Immunology -- Antigen Processing and Presentation -- Antigen Recognition and T-Cell Biology -- Mechanisms of Tumor Evasion -- Tumor Antigens and Tumor Antigen Discovery -- Cancer Vaccine Development -- Peptide Vaccines Against Cancer -- DNA Vaccination in Immunotherapy of Cancer -- Antibody Inducing Polyvalent Cancer Vaccines -- Dendritic Cell-Based Vaccines for Cancer Therapy -- Undefined-Antigen Vaccines -- Cancer Vaccines in Combination with Multimodality Therapy -- Vaccine-Enhancing Strategies -- Cytokine Therapy for Cancer: Antigen Presentation -- Tinkering with Nature: The Tale of Optimizing Peptide Based Cancer Vaccines -- Tumor Immunology and Cancer Vaccines -- Clinical Trials Design -- Clinical Trial Designs for Therapeutic Cancer Vaccines -- Clinical Trial Design and Regulatory Issues for Therapeutic Cancer Vaccines -- Immune Monitoring.
520 _aIt all started with an observation. Edward Jenner, an English physician, observed that milkmaids who contracted cowpox were rarely victims of smallpox epidemic, a disease that in?icted a heavy toll on humankind with an estimate of 500 million victimsworldwide.In1796,Jennerinoculatedtheextracted?uidfromblistersonthe handofamilkmaidwhowasinfectedwithcowpoxintothearman8yearoldpeasant boy. After the boy recovered from a mild illness caused by this inoculation, Jenner exposed him to smallpox and to his delight the boy did not develop the disease. He published his work in 1798 in three publications titled “Vaccination Against smallpox”, where the term vaccination is derived from the Latin word “vacca” meaning cow. Jenner was recognized to be the father of modern immunology, and hisworkmarkedthecommencementofanewdawninmedicinethatledtothe1979 declaration by the World Health Organization (WHO) of the global eradication of smallpox. By the beginning of the 20th century, vaccines for typhoid fever, rabies, polio, plaque and diphtherias were in use, and nowadays we are equipped with effectivevaccinesagainstmorethan20infectiousdiseasessuchasmeningitis,rubella, whooping cough, rabies, and hepatitis B among others.
650 0 _aMedicine.
650 0 _aOncology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aOncology.
700 1 _aKhleif, Samir N.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402081194
830 0 _aCancer Treatment and Research,
_x0927-3042 ;
_v123
856 4 0 _uhttp://dx.doi.org/10.1007/0-387-27545-2
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c500718
_d500718