000 | 02903nam a22004335i 4500 | ||
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001 | 978-0-387-25405-0 | ||
003 | DE-He213 | ||
005 | 20161121230551.0 | ||
007 | cr nn 008mamaa | ||
008 | 100301s2005 xxu| s |||| 0|eng d | ||
020 |
_a9780387254050 _9978-0-387-25405-0 |
||
024 | 7 |
_a10.1007/b107323 _2doi |
|
050 | 4 | _aRC681-688.2 | |
072 | 7 |
_aMJD _2bicssc |
|
072 | 7 |
_aMED010000 _2bisacsh |
|
082 | 0 | 4 |
_a616.12 _223 |
245 | 1 | 0 |
_aAdrenomedullin in Cardiovascular Disease _h[electronic resource] / _cedited by Toshio Nishikimi. |
264 | 1 |
_aBoston, MA : _bSpringer US, _c2005. |
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300 |
_aX, 219 p. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
||
338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aBasic Science for the Cardiologist, _x1566-0753 ; _v19 |
|
505 | 0 | _aBiochemistry of Adrenomedullin -- Adrenomedullin Receptor and Signal Transduction -- Adrenomedullin Gene -- Adrenomedullin Expression and Secretion -- Biological Action of Adrenomedullin -- Circulating Adrenomedullin -- Role of Adrenomedullin in Cardiovascular Diseases -- Adrenomedullin as an Adipokine -- Adrenomedullin Knockout Mouse and Transgenic Mouse -- Pleiotropic Effect of Adrenomedullin: Lessons from Pure Adrenomedullin Knockout Mouse -- Therapeutic Application of Adrenomedullin -- Therapeutic Potentials of Adrenomedullin for Heart Failure and Pulmonary Hypertension. | |
520 | _aAdrenomedullin was discovered in 1993 in an extract of human pheochromocytoma while monitoring cAMP levels in rat platelets. Adrenomedullin has attracted considerable interest among cardiologists due to its impact on the cardiovascular system which includes a decrease in blood pressure in vivo; an impact on vascular smooth muscle cells; increases cAMP levels; indirectly reduces blood pressure and has a role in the pathogenesis of arteriosclerosis. Adrenomedullin in Cardiovascular Disease is an up-to-date review of the most relevant aspects of adrenomedullin. It encompasses a broad range of fields including biochemistry, molecular biology, physiology, pharmacology, pathophysiology of cardiovascular disease and clinical applications of adrenomedullin to cardiovascular disease. Toshio Nishikimi, MD, PhD, is an Associate Professor in the Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aCardiology. | |
650 | 1 | 4 | _aMedicine & Public Health. |
650 | 2 | 4 | _aCardiology. |
700 | 1 |
_aNishikimi, Toshio. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9780387254043 |
830 | 0 |
_aBasic Science for the Cardiologist, _x1566-0753 ; _v19 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/b107323 |
912 | _aZDB-2-SME | ||
950 | _aMedicine (Springer-11650) | ||
999 |
_c500685 _d500685 |