000 02903nam a22004335i 4500
001 978-0-387-25405-0
003 DE-He213
005 20161121230551.0
007 cr nn 008mamaa
008 100301s2005 xxu| s |||| 0|eng d
020 _a9780387254050
_9978-0-387-25405-0
024 7 _a10.1007/b107323
_2doi
050 4 _aRC681-688.2
072 7 _aMJD
_2bicssc
072 7 _aMED010000
_2bisacsh
082 0 4 _a616.12
_223
245 1 0 _aAdrenomedullin in Cardiovascular Disease
_h[electronic resource] /
_cedited by Toshio Nishikimi.
264 1 _aBoston, MA :
_bSpringer US,
_c2005.
300 _aX, 219 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBasic Science for the Cardiologist,
_x1566-0753 ;
_v19
505 0 _aBiochemistry of Adrenomedullin -- Adrenomedullin Receptor and Signal Transduction -- Adrenomedullin Gene -- Adrenomedullin Expression and Secretion -- Biological Action of Adrenomedullin -- Circulating Adrenomedullin -- Role of Adrenomedullin in Cardiovascular Diseases -- Adrenomedullin as an Adipokine -- Adrenomedullin Knockout Mouse and Transgenic Mouse -- Pleiotropic Effect of Adrenomedullin: Lessons from Pure Adrenomedullin Knockout Mouse -- Therapeutic Application of Adrenomedullin -- Therapeutic Potentials of Adrenomedullin for Heart Failure and Pulmonary Hypertension.
520 _aAdrenomedullin was discovered in 1993 in an extract of human pheochromocytoma while monitoring cAMP levels in rat platelets. Adrenomedullin has attracted considerable interest among cardiologists due to its impact on the cardiovascular system which includes a decrease in blood pressure in vivo; an impact on vascular smooth muscle cells; increases cAMP levels; indirectly reduces blood pressure and has a role in the pathogenesis of arteriosclerosis. Adrenomedullin in Cardiovascular Disease is an up-to-date review of the most relevant aspects of adrenomedullin. It encompasses a broad range of fields including biochemistry, molecular biology, physiology, pharmacology, pathophysiology of cardiovascular disease and clinical applications of adrenomedullin to cardiovascular disease. Toshio Nishikimi, MD, PhD, is an Associate Professor in the Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
650 0 _aMedicine.
650 0 _aCardiology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aCardiology.
700 1 _aNishikimi, Toshio.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387254043
830 0 _aBasic Science for the Cardiologist,
_x1566-0753 ;
_v19
856 4 0 _uhttp://dx.doi.org/10.1007/b107323
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c500685
_d500685