000 04817nam a22004455i 4500
001 978-0-387-23188-4
003 DE-He213
005 20161121230551.0
007 cr nn 008mamaa
008 100301s2005 xxu| s |||| 0|eng d
020 _a9780387231884
_9978-0-387-23188-4
024 7 _a10.1007/b100805
_2doi
050 4 _aRC681-688.2
072 7 _aMJD
_2bicssc
072 7 _aMED010000
_2bisacsh
082 0 4 _a616.12
_223
245 1 0 _aRyanodine Receptors
_h[electronic resource] :
_bStructure, function and dysfunction in clinical disease /
_cedited by Xander H. T. Wehrens, Andrew R. Marks.
264 1 _aBoston, MA :
_bSpringer US,
_c2005.
300 _aXXI, 330 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aDevelopments in Cardiovascular Medicine,
_x0166-9842 ;
_v254
505 0 _aEvolution of the Ryanodine Receptor Gene Family -- Topology and Transmembrane Organization of Ryanodine Receptors -- Three-Dimensional Reconstruction of Ryanodine Receptors -- RYR-DHPR Relationships in Skeletal and Cardiac Muscles -- The Pore of the Ryanodine Receptor Channel -- Intra-Molecular Domain-Domain Interaction -- Regulation of Sarcoplasmic Reticulum Calcium Release by Luminal Calcium -- Cytosolic Calcium Regulation of Single Ryanodine Receptor Channels -- Elementary Ca2+ Release Events: Ryanodine Receptor Ca2+ Sparks -- Ca2+ Release from the Sarcoplasmic Reticulum in Intact Cardiomyocytes -- Stability and Instability of Ca2+ Release from the SR -- Ryanodine Receptors in Smooth Muscle -- Functions of RYR3 Homologues -- Knockout Mice Lacking RYR and Junctophilin Subtypes -- Regulation of Ryanodine Receptor Ca2+ Release by Macromolecular Complexes -- RYR1 Modulation by Calmodulin -- Ryanodine Receptor Function in Inflammation -- Ryanoids, Receptor Affinity and RYR Channel Subconductance -- Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function -- Redox Sensing by the Ryanodine Receptors -- Ryanodine Receptor Dysfunction in the Diabetic Heart -- Molecular and Clinical Genetics of RYR1 Disorders -- Pathophysiology of Muscle Disorders Linked to Mutations in the Skeletal Muscle Ryanodine Receptor -- The Dantrolene Binding Site on RYR1 -- Ryanodine Receptor Dysfunction in Heart Failure and Arrhythmias -- Stabilization of Ryanodine Receptor as a Novel Therapeutic Strategy Against Heart Failure -- Ryanodine Receptor Antibodies and Myasthenia Gravis.
520 _aIn recent years, the ryanodine receptor has emerged as a new and very promising target for the treatment of several cardiovascular disorders, including cardiac arrhythmias and heart failure. This volume is the most current publication devoted to the major intracellular calcium-release channel, the ryanodine receptor. "In this series of brief but informative chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology." David E. Clapham, MD, PhD Professor of Neurobiology and Pediatrics Harvard Medical School Dr. Xander H.T. Wehrens received his M.D. and Ph.D. degrees from Maastricht University in the Netherlands. His research has mainly concentrated on molecular mechanisms of cardiac arrhythmias, in particular in the setting of inherited arrhythmogenic syndromes and congestive heart failure. This work has led to the development of novel anti-arrhythmic therapies. He is currently a research scientist in the Department of Physiology and Cellular Biophysics at the College of Physicians and Surgeons of Columbia University. Dr. Andrew R. Marks is the Chair and Professor of the Department of Physiology and Cellular Biophysics at Columbia University College of Physicians and Surgeons. Dr. Marks' research has focused on understanding how macromolecular signaling complexes regulate ion channel function in muscle and non-muscle systems, and on the regulation of vascular smooth muscle proliferation and migration. His work has contributed new understandings of fundamental mechanisms that regulate muscle contraction that have lead to the discovery of molecular defects that contribute to heart failure and fatal cardiac arrhythmias.
650 0 _aMedicine.
650 0 _aCardiology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aCardiology.
700 1 _aWehrens, Xander H. T.
_eeditor.
700 1 _aMarks, Andrew R.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387231877
830 0 _aDevelopments in Cardiovascular Medicine,
_x0166-9842 ;
_v254
856 4 0 _uhttp://dx.doi.org/10.1007/b100805
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c500667
_d500667