Mode of access: World Wide Web.

System requirements: Adobe Acrobat reader.

Part of: Synthesis digital library of engineering and computer science.

Series from website.

Includes bibliographical references (p. 63-80).

Structure-function relationships of the knee meniscus -- Anatomy and development -- Anatomy of the knee meniscus -- Development of the knee meniscus -- Biochemical composition, structure, and function -- Regional variation -- Biochemical content -- Biomechanical properties and evaluation techniques -- Geometrical considerations -- Normal loading conditions -- Shock absorption -- Collagen organization -- Biphasic behavior -- Biomechanical evaluation -- Tension -- Compression -- Shear -- Cell types -- Cell classification -- Diversity of meniscus cells -- Cell synthetic properties -- Regional variation in synthetic profiles -- Mechanosensitivity of meniscus cells -- Pathophysiology and the need for tissue engineering -- Pathophysiology and injury -- Meniscus pathology -- Osteoarthritis and meniscal degeneration -- Tears of the meniscus -- Epidemiology of meniscus tears -- The meniscus healing problem -- Introduction -- Healing in the meniscus -- Characteristics of repair tissue -- Tissue engineering and historical perspectives -- Definition of tissue engineering -- Historical perspectives -- Functional tissue engineering and the meniscus -- Tissue engineering of the knee meniscus -- Bioreactors -- Introduction -- Direct compression -- Hydrostatic pressure -- Shear -- Ultrasound -- Combinations -- Application to meniscus engineering -- In vitro tissue engineering -- Introduction -- Cell source -- Growth factors -- Synthetic scaffolds -- Natural scaffolds -- Scaffold-free approaches -- In vivo tissue engineering -- Introduction -- Animal models -- Fibrin -- Synthetic scaffolds -- Natural scaffolds -- Current therapies and future directions -- Products and current therapies -- Products involving biological materials -- Other current therapies -- Design standards -- Determining design standards -- Primary standards -- Secondary standards -- Assessments for tissue engineered constructs -- Need for functional assessment -- Functionality index -- Variable considerations -- Bibliography.

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The knee meniscus was once thought to be a vestigial tissue, but is now known to be instrumental in imparting stability, shock absorption, load transmission, and stress distribution within the knee joint. Unfortunately, most damage to the meniscus cannot be effectively healed by the body. Meniscus tissue engineering offers a possible solution to this problem by striving to create replacement tissue that may be implanted into a defect site. With a strong focus on structure-function relationships, this book details the essential anatomical, biochemical, and mechanical aspects of this versatile tissue and reviews current meniscus tissue engineering strategies and repair techniques. We have written this text such that undergraduate students, graduate students, and researchers will find it useful as a first foray into tissue engineering, a cohesive study of the meniscus, or a reference for meniscus engineering specifications.

Also available in print.

Title from PDF t.p. (viewed on April 7, 2009).