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Progress in the chemistry of organic natural products [V.123] : neurotrophic natural products

Contributor(s): Fukuyama, Yoshiyasu | Kubo, Miwa | Harada, Kenichi | Kinghorn, A. Douglas [ed.] | Falk, Heinz [ed.] | Gibbons, Simon [ed.] | Asakawa, Yoshinori [ed.] | Liu, Ji-Kai [ed.] | Dirsch, Verena M. [ed.].
Series: Progress in the chemistry of organic natural products. / edited by A. Douglas Kinghorn ...[et al.] ; v.123.Publisher: Switzerland Springer 2024Description: ix, 473p.ISBN: 9783031424212.Subject(s): Natural products | Organic chemistry | NeurotrophicDDC classification: 547 | P943 v.123 Summary: This book deals with neurotrophins (NGF, BDNF, NT3, NT4), which can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons. This makes neurotrophins potential therapeutic agents for the treatment of neurodegenerative disorders. However, these proteins have so far been ineffective in clinical trials mostly because they cannot pass the blood-brain barrier owing to their high-molecular weights. Consequently, small molecules that mimic neurotrophins and stimulate the synthesis of endogenous neurotrophins or enhance their neurotrophic actions are expected to be promising alternatives. Small-molecule natural products, which have been used in dietary functional foods or in traditional medicine over the course of human history, have potential to be developed as new therapeutic agents against neurodegenerative conditions such as Alzheimer’s disease. In this book, the authors introduce a variety of natural products possessing neurotrophic properties such as neurogenesis, neurite outgrowth promotion (neuritogenesis), and neuroprotection and focus on the chemistry and biology of several neurotrophic natural products.
List(s) this item appears in: New arrival February 19 to March 03, 2024
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Item type Current location Collection Call number Vol info Status Date due Barcode Item holds
Books Books PK Kelkar Library, IIT Kanpur
On Display 547 P943 v.123 (Browse shelf) v.123 Available A186411
Total holds: 0

This book deals with neurotrophins (NGF, BDNF, NT3, NT4), which can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons. This makes neurotrophins potential therapeutic agents for the treatment of neurodegenerative disorders. However, these proteins have so far been ineffective in clinical trials mostly because they cannot pass the blood-brain barrier owing to their high-molecular weights. Consequently, small molecules that mimic neurotrophins and stimulate the synthesis of endogenous neurotrophins or enhance their neurotrophic actions are expected to be promising alternatives. Small-molecule natural products, which have been used in dietary functional foods or in traditional medicine over the course of human history, have potential to be developed as new therapeutic agents against neurodegenerative conditions such as Alzheimer’s disease. In this book, the authors introduce a variety of natural products possessing neurotrophic properties such as neurogenesis, neurite outgrowth promotion (neuritogenesis), and neuroprotection and focus on the chemistry and biology of several neurotrophic natural products.

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