Basic Concepts of TGF-? Signaling in Normal Physiology and Cancer Pathobiology -- Component Hardware for Transforming Growth Factor-? Signal Transduction: TGF-? Ligands, TGF-? Receptors, and Smads -- TGF-? Signaling in Homeostasis and Cancer -- TGF-? Availability: Latent TGF-? and Latent TGF-? Binding Proteins -- Biological Functions of Latent TGF-?-Binding Proteins and Activation of TGF-? -- Regulators of Smad2/3 Transcription and Phosphorylation -- Interaction of Smad4 and Embryonic Liver Fodrin-?-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression -- Regulation of Smad Activity by Phosphorylation -- Nuclear Targeting of TGF-?-Activated Smads in Normal and Tumor Biology -- Ski, SnoN, and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival -- Transforming Growth Factor-? in Cancer Therapy: Smurfs in TGF-? Signaling and Regulation of Bone Homeostasis and Cancer -- Involvement of km23 Dynein Light Chains in TGF ? Signaling -- TGF-? Signaling in Fibroblastic Cells and Oncogenesis -- Mechanisms of TGF-?-Induced Apoptosis in Cancer Cells -- Mechanisms of Cell Cycle Regulation by TGF-? Disabled in Cancer -- Transforming Growth Factor-? in Cancer Therapy -- TGF-? and Smad Signaling in Transcriptome Reprogramming During EMT -- Functional Interactions Between MMPs and TGF-? in Normal and Tumor Tissue -- Cooperation Between TGF-? and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function -- Interaction of Oncogenic Ras and TGF?1 Signaling in Cancer: Lessons From the Multistage Skin Carcinogenesis Model -- TGF-? Superfamily Members in Normal and Tumor Biology -- Proteomics Analysis of TGF? Superfamily Members -- Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain Human Cancers -- Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression -- Bone Morphogenic Proteins and Angiogenesis in Developing Tumors -- Histone Methyltransferase and Smad Interactions in BMP Signaling -- Endoglin (CD105): A Strong Candidate for Immunologic Targeting of Tumor Neovasculature in Human Malignancies -- Activins and Inhibins in Cancer Progression -- Bone Morphogenetic Proteins/Growth Differentiation Factors and Smad Activation in Ovarian Granulosa Cells and Carcinoma -- Regulation of the Transforming Growth Factor-? Superfamily by Betaglycan -- Uterine Sensitization Associated Gene-1: A Bone Morphogenetic Protein Antagonist with a Role in Kidney -- Role of Betaig-h3 Gene in Carcinogenesis -- Activins and the Liver -- Myostatin Signaling in Normal and Tumor Cells -- TGF-? in Inflammation and Fibrosis -- Triterpenoids, Vitamin D, and TGF-?/Smad Signaling in Inflammation and Cancer -- Thrombospondin-Dependent Activation of Latent TGF-? in Fibrosis and Disease -- TGF-? in Pulmonary Fibrosis -- The Role of TGF-? in Bleomycin Induced Pulmonary Fibrosis -- Smads in the Fibrotic Response: Findings in the Smad3 Knockout Mouse -- TGF-? Signaling in Renal Fibrosis and Inflammation: Gene Therapy Using Ultrasound-Microbubble-Mediated Inducible Smad7 -- Transforming Growth Factor-? Peptide Signaling in Pulmonary Development, Bronchopulmonary Dysplasia, Fibrosis, and Emphysema -- The Role of TGF-? in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-? as a Novel Therapeutic Strategy -- Negative Regulation of the TGF-? Family Signal Pathway by Inhibitory Smads and Their Involvement in Cancer and Fibrosis -- TGF-?-Related Antifibrotic Strategies in the Eye -- Transforming Growth Factor-? in Cutaneous Tissue Repair -- Topical Application of TGF-?1 Peptide Inhibitors for the Therapy of Skin Fibrosis -- Overexpressed Truncated TGF-? Type II Receptor Inhibits Fibrotic Behavior of Keloid Fibroblasts In Vitro and Experimental Scar Formation In Vivo.

Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. Part I presents basic concepts of transforming growth factor-ß signaling in normal physiology and cancer pathobiology. Part II investigates transforming growth factor-ß superfamily members in normal and tumor biology. Part III details transforming growth factor-ß in inflammation and fibrosis. This volume’s companion, Cancer Treatment and Therapy, examines transforming growth factor-ß in several developing and advanced cancers and discusses methods of treatment and therapy. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment.