The Neuregulin-I/ErbB Signaling System in Development and Disease
By: Britsch, Stefan [author.].
Contributor(s): SpringerLink (Online service).
Material type:
BookSeries: Advances in Anatomy Embryology and Cell Biology: 190Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 2007.Description: XI, 70 p. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783540371076.Subject(s): Medicine | Molecular biology | Biomedicine | Molecular MedicineDDC classification: 611.01816 Online resources: Click here to access online | Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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E books
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PK Kelkar Library, IIT Kanpur | Available | EBK4288 |
Introduction – Molecular control of development -- Biology of the Neuregulin/ErbB signaling network -- Neuregulins and their receptors -- Developmental functions of the Neuregulin-1/ErbB signalling pathway -- Interacting molecules – the Sox10/ErbB connection -- NRG-1/ErbB signals and disease -- Abbreviations -- References -- Subject index.
Neuregulins are EGF-like growth and differentiation factors that interact with tyrosine kinase receptors of the ErbB family. this signailing system has a wide range of functions during development of the nervous system, the heart, and the mammary gland. Furthermore, Neuregulin signals are also involved in the development of human diseases including breast cancer, heart disease and the pathogenesis of schizophrenia. This monograph reviews the biology of Neuregulins and their receptors and summarizes recent research, which has established crucial functions of this signaling system during development and disease. .
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