PKK Library

Your cart is empty.

Welcome to P K Kelkar Library, Online Public Access Catalogue (OPAC)

Normal view MARC view ISBD view

Nucleic Acid Switches and Sensors

By: Silverman, Scott K [author.].
Contributor(s): SpringerLink (Online service).
Material type: materialTypeLabelBookPublisher: Boston, MA : Springer US, 2006.Description: IX, 125 p. 57 illus., 3 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9780387472577.Subject(s): Medicine | Human genetics | Medical microbiology | Biomedicine | Human Genetics | Medical MicrobiologyDDC classification: 611.01816 | 599.935 Online resources: Click here to access online
Contents:
Artificial Nucleic Acid Switches and Sensors -- Allosteric Ribozymes as Molecular Switches and Sensors -- Ribozymes and Deoxyribozymes Switched by Oligonucleotides -- Ribozymes Switched by Proteins -- Fluorescence-Signaling Nucleic Acid-Based Sensors -- Natural Nucleic Acid Switches and Sensors -- Protein-Induced RNA Switches in Nature -- Riboswitches as Genetic Control Elements -- Switchable RNA Motifs as Drug Targets.
In: Springer eBooksSummary: In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.
    average rating: 0.0 (0 votes)
Item type Current location Call number Status Date due Barcode Item holds
E books E books PK Kelkar Library, IIT Kanpur
Available EBK2542
Total holds: 0

Artificial Nucleic Acid Switches and Sensors -- Allosteric Ribozymes as Molecular Switches and Sensors -- Ribozymes and Deoxyribozymes Switched by Oligonucleotides -- Ribozymes Switched by Proteins -- Fluorescence-Signaling Nucleic Acid-Based Sensors -- Natural Nucleic Acid Switches and Sensors -- Protein-Induced RNA Switches in Nature -- Riboswitches as Genetic Control Elements -- Switchable RNA Motifs as Drug Targets.

In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.

There are no comments for this item.

Log in to your account to post a comment.

Powered by Koha