| 000 -LEADER |
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| fixed length control field |
06497nam a2200769 i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
6949409 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
IEEE |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20200413152915.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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| fixed length control field |
m eo d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr cn |||m|||a |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
141120s2015 caua foab 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9781627054515 |
| Qualifying information |
ebook |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| Canceled/invalid ISBN |
9781627054508 |
| Qualifying information |
print |
| 024 7# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.2200/S00600ED1V01Y201409WEB009 |
| Source of number or code |
doi |
| 035 ## - SYSTEM CONTROL NUMBER |
|---|
| System control number |
(CaBNVSL)swl00404343 |
| 035 ## - SYSTEM CONTROL NUMBER |
|---|
| System control number |
(OCoLC)896434163 |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
CaBNVSL |
| Language of cataloging |
eng |
| Description conventions |
rda |
| Transcribing agency |
CaBNVSL |
| Modifying agency |
CaBNVSL |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
RM301.25 |
| Item number |
.C447 2015 |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
|---|
| Classification number |
QV 744 |
| Item number |
C447s 2015 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
615.19 |
| Edition number |
23 |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
|
| Local cutter number (OCLC) ; Book number/undivided call number, CALL (RLIN) |
MoCl |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Chen, Bin, |
| Dates associated with a name |
1983-, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Semantic breakthrough in drug discovery / |
| Statement of responsibility, etc. |
Bin Chen, Huijun Wang, Ying Ding, David Wild. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : |
| Name of producer, publisher, distributor, manufacturer |
Morgan & Claypool, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2015. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
1 PDF (ix, 132 pages) : |
| Other physical details |
illustrations. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
electronic |
| Source |
isbdmedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
online resource |
| Source |
rdacarrier |
| 490 1# - SERIES STATEMENT |
|---|
| Series statement |
Synthesis lectures on the semantic web, theory and technology, |
| International Standard Serial Number |
2160-472X ; |
| Volume/sequential designation |
# 9 |
| 538 ## - SYSTEM DETAILS NOTE |
|---|
| System details note |
Mode of access: World Wide Web. |
| 538 ## - SYSTEM DETAILS NOTE |
|---|
| System details note |
System requirements: Adobe Acrobat Reader. |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Part of: Synthesis digital library of engineering and computer science. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Includes bibliographical references (pages 113-129). |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
1. Introduction -- 1.1 Background -- 1.2 Data representation in the Semantic Web -- 1.3 Data query, management, and integration -- 1.4 Knowledge discovery in semantically integrated datasets -- 1.5 Chem2Bio2RDF -- |
| 505 8# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
2. Data representation and integration using RDF -- 2.1 Background -- 2.2 Methods -- 2.3 Discussion -- 2.4 Conclusion -- |
| 505 8# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
3. Data representation and integration using OWL -- 3.1 Introduction -- 3.2 System and methods -- 3.3 Implementation -- 3.4 Use cases -- 3.5 Discussion -- 3.6 Conclusion -- |
| 505 8# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
4. Finding complex biological relationships in PubMed articles using Bio-LDA -- 4.1 Introduction -- 4.2 Materials and methods -- 4.2.1 Databases -- 4.2.2 Bio-LDA -- 4.3 Experimental results -- 4.3.1 Analyzing the Bio-LDA model results -- 4.3.2 Comparing the Bio-LDA and LDA models -- 4.3.3 Identification of bio-term relationships within topics -- 4.3.4 Discovery of bio-term associations -- 4.4 Application tools -- 4.4.1 Literature Association Score Calculator (LASC) -- 4.4.2 Associated Bio-Terms Finder (ABTF) -- 4.5 Conclusion -- |
| 505 8# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
5. Integrated semantic approach for systems chemical biology knowledge discovery -- 5.1 Introduction -- 5.2 Datasets -- 5.3 Methods -- 5.3.1 Association prediction -- 5.3.2 Association search -- 5.3.3 Association exploration -- 5.3.4 Connectivity-map generation -- 5.3.5 Chem2Bio2RDF extension -- 5.4 Application tools -- 5.4.1 Association predictor -- 5.4.2 Association searcher -- 5.4.3 Association explorer -- 5.5 Use cases -- 5.5.1 Identifying potential drugs for a target -- 5.5.2 Investigating drug polypharmacology using association search -- 5.5.3 Building a disease-specific drug-protein connectivity map -- 5.5.4 Association search for discovery compounds -- 5.6 Conclusion -- |
| 505 8# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
6. Semantic link association prediction -- 6.1 Introduction -- 6.2 Materials and methods -- 6.2.1 Network building -- 6.2.2 Drug target pair preparation -- 6.2.3 Path finding -- 6.2.4 Statistical model -- 6.2.5 Model evaluation -- 6.2.6 Assess drug similarity -- 6.3 Results -- 6.3.1 Semantic linked data -- 6.3.2 Pattern score distribution -- 6.3.3 Pattern importance -- 6.3.4 Association scores of drug target pairs -- 6.3.5 Comparison with connectivity maps -- 6.3.6 Assessing drug similarity from biological function -- 6.4 Web services -- 6.5 Discussion -- |
| 505 8# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
7. Conclusions -- References -- Authors' biographies. |
| 506 1# - RESTRICTIONS ON ACCESS NOTE |
|---|
| Terms governing access |
Abstract freely available; full-text restricted to subscribers or individual document purchasers. |
| 510 0# - CITATION/REFERENCES NOTE |
|---|
| Name of source |
Compendex |
| 510 0# - CITATION/REFERENCES NOTE |
|---|
| Name of source |
INSPEC |
| 510 0# - CITATION/REFERENCES NOTE |
|---|
| Name of source |
Google scholar |
| 510 0# - CITATION/REFERENCES NOTE |
|---|
| Name of source |
Google book search |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
The current drug development paradigm, sometimes expressed as, "one disease, one target, one drug," is under question, as relatively few drugs have reached the market in the last two decades. Meanwhile, the research focus of drug discovery is being placed on the study of drug action on biological systems as a whole, rather than on individual components of such systems. The vast amount of biological information about genes and proteins and their modulation by small molecules is pushing drug discovery to its next critical steps, involving the integration of chemical knowledge with these biological databases. Systematic integration of these heterogeneous datasets and the provision of algorithms to mine the integrated datasets would enable investigation of the complex mechanisms of drug action; however, traditional approaches face challenges in the representation and integration of multi-scale datasets, and in the discovery of underlying knowledge in the integrated datasets. The Semantic Web, envisioned to enable machines to understand and respond to complex human requests and to retrieve relevant, yet distributed, data, has the potential to trigger system-level chemical-biological innovations. Chem2Bio2RDF is presented as an example of utilizing Semantic Web technologies to enable intelligent analyses for drug discovery. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Also available in print. |
| 588 ## - SOURCE OF DESCRIPTION NOTE |
|---|
| Source of description note |
Title from PDF title page (viewed on November 20, 2014). |
| 630 00 - SUBJECT ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Chem2Bio2RDF. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Drug development. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Drugs |
| General subdivision |
Research. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Semantic Web. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Drug Discovery. |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
drug discovery |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
semantic data integration |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
semantic analytics |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
semantic graph mining |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
semantic prediction |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Wang, Huijun., |
| Relator term |
author. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ding, Ying, |
| Dates associated with a name |
1955-, |
| Relator term |
author. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Wild, David., |
| Relator term |
author. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Print version: |
| International Standard Book Number |
9781627054508 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Synthesis digital library of engineering and computer science. |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Synthesis lectures on the semantic web, theory and technology ; |
| Volume/sequential designation |
# 9. |
| International Standard Serial Number |
2160-472X |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Materials specified |
Abstract with links to full text |
| Uniform Resource Identifier |
http://dx.doi.org/10.2200/S00600ED1V01Y201409WEB009 |
| 856 42 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Materials specified |
Abstract with links to resource |
| Uniform Resource Identifier |
http://ieeexplore.ieee.org/servlet/opac?bknumber=6949409 |
