| 000 -LEADER |
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| fixed length control field |
04455nam a22005415i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-3-7643-8552-1 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20161121230849.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
100301s2008 sz | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783764385521 |
| -- |
978-3-7643-8552-1 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-3-7643-8552-1 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
TP248.13-248.65 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
TCB |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
SCI010000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
660.6 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Bone Morphogenetic Proteins: From Local to Systemic Therapeutics |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc. |
edited by Slobodan Vukicevic, Kuber T. Sampath. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Basel : |
| Name of producer, publisher, distributor, manufacturer |
Birkh�user Basel, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2008. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XI, 343 p. 115 illus., 36 illus. in color. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda1 |
| 490 ## - SERIES STATEMENT |
|---|
| Series statement |
Progress in Inflammation Research0 |
| 505 ## - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Development of a novel compression-resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results -- Use of recombinant human BMP-2 in orthopedic trauma -- The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects -- Clinical outcomes using rhBMP-2 in spinal fusion applications -- Bone morphogenetic protein signaling is fine-tuned on multiple levels -- Dissection of bone morphogenetic protein signaling using genome-engineering tools -- Alterations of BMP signaling pathway(s) in skeletal diseases -- Signaling cross-talk by bone morphogenetic proteins -- The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development -- The role of bone morphogenetic protein 4 (BMP-4) in tooth development -- Bone morphogenetic protein antagonists and kidney -- Induction of cementogenesis and periodontal ligament regeneration by the bone morphogenetic proteins -- Control of bone mass by sclerostin: Inhibiting BMP- and WNT-induced bone formation -- Bone morphogenetic proteins in cartilage biology -- Systemic administration of bone morphogenetic proteins. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a potential to provide protection against inflammation and fibrosis in acute and chronic injury of parenchymal tissues when applied systemically to sustain the function of kidney and liver. The application of BMPs from a local to systemic utility is a rapidly growing field, gaining interest among researchers and biotech entrepreneurs. In this volume, we summarize the advances made on the local and systemic use of BMPs including chapters covering the regulation of BMP-signalling pathways, biological actions of BMPs in bone, cartilage and teeth, as well as clinical applications and potential systemic use of BMPs for tissues beyond bone. This volume is of interest to researchers from immunology, cell biology, biochemistry, and clinicians from orthopedics and dentistry, as well as to research managers from biotech and pharmaceutical companies. |
| 650 0# - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Chemistry. |
| 650 0# - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Immunology. |
| 650 0# - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Biotechnology. |
| 650 0# - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Rheumatology. |
| 650 0# - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Orthopedics. |
| 650 0# - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cell biology.1 |
| 650 4# - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Chemistry.2 |
| 650 4# - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Biotechnology.2 |
| 650 4# - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Immunology.2 |
| 650 4# - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Rheumatology.2 |
| 650 4# - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Orthopedics.2 |
| 650 4# - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cell Biology.1 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Vukicevic, Slobodan. |
| Relator term |
editor.1 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sampath, Kuber T. |
| Relator term |
editor.2 |
| 710 ## - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service)0 |
| 773 ## - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks0 |
| 776 8# - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9783764385514 |
| 830 0# - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Progress in Inflammation Research4 |
| 856 0# - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-7643-8552-1 |
| 912 ## - |
|---|
| -- |
ZDB-2-SME |
