| 000 -LEADER |
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| fixed length control field |
04774nam a22004695i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-1-59745-375-2 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20161121230841.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
100301s2008 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9781597453752 |
| -- |
978-1-59745-375-2 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-1-59745-375-2 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RE1-994 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MJQ |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
MED063000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
617.7 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Ocular Transporters In Ophthalmic Diseases And Drug Delivery |
| Medium |
[electronic resource] : |
| Remainder of title |
Ophthalmology Research / |
| Statement of responsibility, etc. |
edited by Joyce Tombran-Tink, Colin J. Barnstable. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Totowa, NJ : |
| Name of producer, publisher, distributor, manufacturer |
Humana Press, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2008. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XVIII, 467 p. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 490 1# - SERIES STATEMENT |
|---|
| Series statement |
Ophthalmology Research |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Transport in the Anterior Segment -- Aquaporins and Water Transport in the Cornea -- Roles of Corneal Epithelial Ion Transport Mechanisms in Mediating Responses to Cytokines and Osmotic Stress -- Vitamin C Transport, Delivery, and Function in the Anterior Segment of the Eye -- Transporters of the Ciliary Epithelium -- Mechanisms of Aqueous Humor Formation -- Lens Transporters -- Membrane Transporters -- Lens Na+, K+-ATPase -- Transport Across the Blood–Retinal Barrier -- Pathophysiology of Pericyte-containing Retinal Microvessels -- Molecular Mechanisms of the Inner Blood-Retinal Barrier Transporters -- Transport Across the Retinal Pigment Epithelium -- Regulation of Transport in the RPE -- Glucose Transporters in Retinal Pigment Epithelium Development -- Ca2+ Channels in the Retinal Pigment Epithelium -- Taurine Transport Pathways in the Outer Retina in Relation to Aging and Disease -- P-Glycoprotein Expression and Function in the Retinal Pigment Epithelium -- Transporters in the Retina -- The Retinal Rod NCKX1 and Cone/Ganglion Cell NCKX2 Na+/Ca2+-K+ Exchangers -- Excitatory Amino Acid Transporters in the Retina -- Localization and Function of Gamma Aminobutyric Acid Transporter 1 in the Retina -- Genetic Variants of Ocular Transporters -- Biochemical Defects Associated with Genetic Mutations in the Retina-Specific ABC Transporter, ABCR, and Macular Degenerative Diseases -- Glutamate Transporters and Retinal Disease and Regulation -- Glutamate Transport in Retinal Glial Cells during Diabetes -- Ocular Drug Delivery -- The Emerging Significance of Drug Transporters and Metabolizing Enzymes to Ophthalmic Drug Design -- Barriers in Ocular Drug Delivery -- Ophthalmic Applications of Nanotechnology -- Vitamin C Transporters in the Retina -- The Plasma Membrane Transporters and Channels of Corneal Endothelium. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye. Ocular Transporters in Ophthalmic Diseases and Drug Delivery is the first text book in this field and offers up-to-date information to clinicians, research scientists in academia, and the pharmaceutical industry. This work has clinical implications for drug development and therapeutic drug delivery, making it an invaluable resource for readers. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Ophthalmology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cell biology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medicine & Public Health. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Ophthalmology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cell Biology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Tombran-Tink, Joyce. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Barnstable, Colin J. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9781588299581 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Ophthalmology Research |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-1-59745-375-2 |
| 912 ## - |
|---|
| -- |
ZDB-2-SME |
