000 -LEADER |
fixed length control field |
04496nam a22005655i 4500 |
001 - CONTROL NUMBER |
control field |
978-1-4020-6561-3 |
003 - CONTROL NUMBER IDENTIFIER |
control field |
DE-He213 |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20161121230839.0 |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
fixed length control field |
cr nn 008mamaa |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
100301s2008 ne | s |||| 0|eng d |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
9781402065613 |
-- |
978-1-4020-6561-3 |
024 7# - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1007/978-1-4020-6561-3 |
Source of number or code |
doi |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
Classification number |
RC1-1245 |
072 #7 - SUBJECT CATEGORY CODE |
Subject category code |
MJ |
Source |
bicssc |
072 #7 - SUBJECT CATEGORY CODE |
Subject category code |
MED045000 |
Source |
bisacsh |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
616 |
Edition number |
23 |
245 14 - TITLE STATEMENT |
Title |
The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism |
Medium |
[electronic resource] / |
Statement of responsibility, etc. |
edited by Bharti Mackness, Mike Mackness, Michael Aviram, György Paragh. |
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
Place of production, publication, distribution, manufacture |
Dordrecht : |
Name of producer, publisher, distributor, manufacturer |
Springer Netherlands, |
Date of production, publication, distribution, manufacture, or copyright notice |
2008. |
300 ## - PHYSICAL DESCRIPTION |
Extent |
XV, 325 p. |
Other physical details |
online resource. |
336 ## - CONTENT TYPE |
Content type term |
text |
Content type code |
txt |
Source |
rdacontent |
337 ## - MEDIA TYPE |
Media type term |
computer |
Media type code |
c |
Source |
rdamedia |
338 ## - CARRIER TYPE |
Carrier type term |
online resource |
Carrier type code |
cr |
Source |
rdacarrier |
347 ## - DIGITAL FILE CHARACTERISTICS |
File type |
text file |
Encoding format |
PDF |
Source |
rda |
490 1# - SERIES STATEMENT |
Series statement |
Proteins And Cell Regulation ; |
Volume/sequential designation |
6 |
505 0# - FORMATTED CONTENTS NOTE |
Formatted contents note |
The Bert La Du Memorial Lecture -- Paraoxonases: An Historical Perspective -- PONs and Atherosclerosis -- Glucose Inactivates Paraoxonase 1 (PON1) and Displaces it from High Density Lipoprotein (HDL) to a Free PON1 Form -- Paraoxonase-1 and Cardiovascular Disease -- Oxidative Stress & Antioxidants and PON1 in Health and Disease -- D-4F Increases Paraoxonase 1 Activity in HDL -- Paraoxonase 1 (PON1), A Junction Between the Metabolisms of Homocysteine and Lipids -- The Role of PON2 and PON3 in Atherosclerosis and Related Traits -- Paraoxonase 1 and Postprandial Lipemia -- PON1 Genotypes and Coronary Heart Disease -- PON1 Structure -- Human Paraoxonase I: A Potential Bioscavenger of Organophosphorus Nerve Agents -- Stabilisation of Active Form of Natural Human PON1 Requires HPBP -- PONs in Disease other than Atherosclerosis -- Paraoxonase-1 in Chronic Liver Diseases, Neurological Diseases and HIV Infection -- Age-Related Alterations in PON1 -- PON and Toxicology -- Paraoxonase (PON1) and Organophosphate Toxicity -- Implications of Paraoxonase-1 (PON1) Activity and Polymorphisms on Biochemical and Clinical Outcomes in Workers Exposed to Pesticides -- PON-Genetics and Regulation -- Transcriptional Regulation of the Paraoxonase Genes -- Effect of Lipid Lowering Medications on PON1 -- The Functional Consequences of Polymorphisms in the Human PON1 Gene -- Dietary Modulation of Paraoxonase-1 Activity and Concentration in Humans -- PONs Biochemistry -- PONs’ Natural Substrates – The Key for their Physiological Roles -- Paraoxonases, Quorum Sensing, And Pseudomonas Aeruginosa. |
520 ## - SUMMARY, ETC. |
Summary, etc. |
Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few “mad” scientists searching for “natural” substrates. Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity. In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Medicine. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Internal medicine. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Cardiology. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Diabetes. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Metabolic diseases. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Medical biochemistry. |
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Medicine & Public Health. |
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Internal Medicine. |
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Cardiology. |
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Diabetes. |
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Metabolic Diseases. |
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Medical Biochemistry. |
700 1# - ADDED ENTRY--PERSONAL NAME |
Personal name |
Mackness, Bharti. |
Relator term |
editor. |
700 1# - ADDED ENTRY--PERSONAL NAME |
Personal name |
Mackness, Mike. |
Relator term |
editor. |
700 1# - ADDED ENTRY--PERSONAL NAME |
Personal name |
Aviram, Michael. |
Relator term |
editor. |
700 1# - ADDED ENTRY--PERSONAL NAME |
Personal name |
Paragh, György. |
Relator term |
editor. |
710 2# - ADDED ENTRY--CORPORATE NAME |
Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
773 0# - HOST ITEM ENTRY |
Title |
Springer eBooks |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
Relationship information |
Printed edition: |
International Standard Book Number |
9781402065606 |
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
Uniform title |
Proteins And Cell Regulation ; |
Volume/sequential designation |
6 |
856 40 - ELECTRONIC LOCATION AND ACCESS |
Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-1-4020-6561-3 |
912 ## - |
-- |
ZDB-2-SME |