| 000 -LEADER |
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| fixed length control field |
04423nam a22004455i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-3-540-77349-8 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20161121230810.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
100301s2008 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783540773498 |
| -- |
978-3-540-77349-8 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-3-540-77349-8 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QR355-502 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MMFM |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
MED052000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
616.9101 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Human Cytomegalovirus |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc. |
edited by Thomas E. Shenk, Mark F. Stinski. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Berlin, Heidelberg : |
| Name of producer, publisher, distributor, manufacturer |
Springer Berlin Heidelberg, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2008. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XIII, 479 p. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 490 1# - SERIES STATEMENT |
|---|
| Series statement |
Current Topics in Microbiology and Immunology, |
| International Standard Serial Number |
0070-217X ; |
| Volume/sequential designation |
325 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Human Cytomegalovirus Genome -- Human Cytomegalovirus microRNAs -- Mutagenesis of the Cytomegalovirus Genome -- Cytomegalovirus Cell Tropism -- Virus Entry and Innate Immune Activation -- Functions of Human Cytomegalovirus Tegument Proteins Prior to Immediate Early Gene Expression -- Initiation of Cytomegalovirus Infection at ND10 -- Functional Roles of the Human Cytomegalovirus Essential IE86 Protein -- Nuts and Bolts of Human Cytomegalovirus Lytic DNA Replication -- Interactions of Human Cytomegalovirus Proteins with the Nuclear Transport Machinery -- Structure and Formation of the Cytomegalovirus Virion -- Human Cytomegalovirus Modulation of Signal Transduction -- Chemokines and Chemokine Receptors Encoded by Cytomegaloviruses -- Subversion of Cell Cycle Regulatory Pathways -- Modulation of Host Cell Stress Responses by Human Cytomegalovirus -- Control of Apoptosis by Human Cytomegalovirus -- Aspects of Human Cytomegalovirus Latency and Reactivation -- Murine Model of Cytomegalovirus Latency and Reactivation -- Cytomegalovirus Immune Evasion -- Cytomegalovirus Vaccine Development -- Cytomegalovirus Infection in the Human Placenta: Maternal Immunity and Developmentally Regulated Receptors on Trophoblasts Converge -- Mechanisms of Cytomegalovirus-Accelerated Vascular Disease: Induction of Paracrine Factors That Promote Angiogenesis and Wound Healing -- Manifestations of Human Cytomegalovirus Infection: Proposed Mechanisms of Acute and Chronic Disease. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The earliest observation of cytomegalovirus (CMV) interactions with the host cell was owl eye cytopathology in various tissues. It was recognized in the early 1970s that human CMV caused in utero infections resulting in congenital brain damage and other sensory neurological complications. Events of the 1980s and early 1990s, such as the wide application of solid organ and bone marrow transplantation and the emergence of AIDS, put the spotlight on human CMV. We understood that the virus was an opportunistic agent associated with immunosuppression. The golden age of cytomegalovirus research was ushered in during the late 1970s and early 1980s by a set of powerful new technologies that included restriction enzymes, DNA cloning, DNA sequencing, and open reading frame prediction. The genetic manipulation and propagation of novel CMV strains was accelerated with the app- cation of bacterial artificial chromosome technology. Today, we still struggle to understand the full spectrum of disease associated with human CMV. To the molecular biologist, CMV is a master of regulation in the eukaryotic cell where it either replicates or remains latent. To the immunologist, CMV is a master of immune evasion with tools to escape both the innate and acquired immune responses. The use of animal models with non-human CMVs has become significantly more sophisticated and tied to a more certain understanding of the interrelationships of non-human and human CMV genes. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Virology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Virology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shenk, Thomas E. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Stinski, Mark F. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9783540773481 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Current Topics in Microbiology and Immunology, |
| International Standard Serial Number |
0070-217X ; |
| Volume/sequential designation |
325 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-540-77349-8 |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
