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Advances in multiple Sclerosis and Experimental Demyelinating Diseases (Record no. 504086)

000 -LEADER
fixed length control field 04007nam a22004575i 4500
001 - CONTROL NUMBER
control field 978-3-540-73677-6
003 - CONTROL NUMBER IDENTIFIER
control field DE-He213
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20161121230808.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 100301s2008 gw | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783540736776
-- 978-3-540-73677-6
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1007/978-3-540-73677-6
Source of number or code doi
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC346-429.2
072 #7 - SUBJECT CATEGORY CODE
Subject category code MJN
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED056000
Source bisacsh
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 616.8
Edition number 23
245 10 - TITLE STATEMENT
Title Advances in multiple Sclerosis and Experimental Demyelinating Diseases
Medium [electronic resource] /
Statement of responsibility, etc. edited by Moses Rodriguez.
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Berlin, Heidelberg :
Name of producer, publisher, distributor, manufacturer Springer Berlin Heidelberg,
Date of production, publication, distribution, manufacture, or copyright notice 2008.
300 ## - PHYSICAL DESCRIPTION
Extent XIV, 362 p.
Other physical details online resource.
336 ## - CONTENT TYPE
Content type term text
Content type code txt
Source rdacontent
337 ## - MEDIA TYPE
Media type term computer
Media type code c
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term online resource
Carrier type code cr
Source rdacarrier
347 ## - DIGITAL FILE CHARACTERISTICS
File type text file
Encoding format PDF
Source rda
490 1# - SERIES STATEMENT
Series statement Current Topics in Microbiology and Immunology,
International Standard Serial Number 0070-217X ;
Volume/sequential designation 318
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Benign Multiple Sclerosis: A Distinct Clinical Entity with Therapeutic Implications -- Pathological Heterogeneity of Idiopathic Central Nervous System Inflammatory Demyelinating Disorders -- Multiple Sclerosis Genetics -- Imaging of Remyelination and Neuronal Health -- Immunological Aspects of Axon Injury in Multiple Sclerosis -- The Multiple Sclerosis Degradome: Enzymatic Cascades in Development and Progression of Central Nervous System Inflammatory Disease -- Genetic Analysis of CNS Remyelination -- Remyelination in Experimental Models of Toxin-Induced Demyelination -- Remyelination-Promoting Human IgMs: Developing a Therapeutic Reagent for Demyelinating Disease -- Neuroimaging of Demyelination and Remyelination Models -- Hormonal Influences in Multiple Sclerosis -- Statins and Demyelination -- Role of Uric Acid in Multiple Sclerosis -- Neuromyelitis Optica: Clinical Syndrome and the NMO-IgG Autoantibody Marker.
520 ## - SUMMARY, ETC.
Summary, etc. "There is a need for a paradigm shift in our thinking about the pathogenesis of multiple sclerosis." Challenging Charcot’s hypothesis that inflammatory response is the primary contributor to demyelination, Dr. Rodriguez and colleagues take a fresh, bold look at the causes and possible treatments of MS. Assuming oligodendrocyte injury as a prerequisite to MS, the authors explore viruses, toxins and genetic defects as possible culprits. They present novel methods to interrupt and reverse demyelination. This book examines the correlation between axonal loss and clinical deficits, including the implied role of the CD8+ T cell and perforin. It assesses proteases, specifically, kallikrein 6, which are strongly associated with active demyelination. By directing natural autoantibodies against oligodendrocytes that demonstrate remyelination in animal models, the authors envision clinical trials for remyelination enhancement. As internationally recognized specialists in a wide range of MS disciplines, the authors explore genetic tools for identifying patients who are most likely to experience spontaneous remyelination. Epidemiology studies offer additional avenues of treatment. Examples include uric acid, statin drugs, estrogen and progesterone. MS affects nearly 400,000 people in the United States, many of whom are between18 and 40 years of age. With their novel, multifaceted approach to basic science—and their applications in understanding cause and treatment—the authors offer help to clinicians and hope to patients.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Medicine.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Immunology.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Neurology.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Medicine & Public Health.
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Neurology.
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Immunology.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Rodriguez, Moses.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Relationship information Printed edition:
International Standard Book Number 9783540736769
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE
Uniform title Current Topics in Microbiology and Immunology,
International Standard Serial Number 0070-217X ;
Volume/sequential designation 318
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-3-540-73677-6
912 ## -
-- ZDB-2-SBL
Holdings
Withdrawn status Lost status Damaged status Not for loan Permanent Location Current Location Date acquired Barcode Date last seen Price effective from Koha item type
        PK Kelkar Library, IIT Kanpur PK Kelkar Library, IIT Kanpur 2016-11-21 EBK4373 2016-11-21 2016-11-21 E books

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