| 000 -LEADER |
|---|
| fixed length control field |
03881nam a22004815i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-3-540-37531-9 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20161121230805.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
|---|
| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
100301s2007 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9783540375319 |
| -- |
978-3-540-37531-9 |
| 024 7# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.1007/b104871 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
QH573-671 |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
PSF |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
SCI049000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
571.6 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Genome Integrity |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc. |
edited by Dirk-Henner Lankenau. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Berlin, Heidelberg : |
| Name of producer, publisher, distributor, manufacturer |
Springer Berlin Heidelberg, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2007. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XI, 496 p. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 490 1# - SERIES STATEMENT |
|---|
| Series statement |
Genome Dynamics and Stability, |
| International Standard Serial Number |
1861-3373 ; |
| Volume/sequential designation |
1 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Replication -- Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories -- Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork -- DNA Polymerases and Diseases -- Replicative Double-Strand Break Repair -- Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing -- Germline Double-Strand Break Repair and Gene Targeting in Drosophila: A�Trajectory System throughout Evolution -- Facets of Double-Strand Break Repair -- Structure and Function of Rad50/SMC Protein Complexes in Chromosome Biology -- Mechanisms of Non-Homologous DNA End Joining:Aspects of In Vitro Assays -- Role of p53 in Double-Strand Break Repair -- The Role of Chromatin Structure and Nuclear Architecture in the Cellular Response to DNA Double-Strand Breaks -- DNA Repair and Pleiotropic Interactions -- DNA Base Damage Recognition and Processing -- Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity -- Role of Human Topoisomerase I in DNA Repair and Apoptosis -- Genomic Instability in Fanconi Anaemia and Nijmegen Breakage Syndrome -- Radiation and other Genotoxic Stress -- Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress -- Pathways of DNA Double-Strand Break Repair in Mammalian Cells after Ionizing Radiation -- Genomic Instability:Signaling Pathways Orchestrating the Responsesto Ionizing Radiation and Cisplatin -- Ion Irradiation as a�Tool to Reveal the Spatiotemporal Dynamics of DNA Damage Response Processes. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assault from metabolic mutagens, such as hydroxy-radicals, endonucleases, radiation, replication errors, and environmental mutagens. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed. 0 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Life sciences. 0 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Human genetics. 0 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Biochemistry. 0 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cell biology.14 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Life Sciences.24 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cell Biology.24 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Biochemistry, general.24 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Human Genetics.1 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Lankenau, Dirk-Henner. |
| Relator term |
editor.2 |
| 710 ## - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service)0 |
| 773 ## - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks08 |
| 776 ## - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9783540375289 0 |
| 830 ## - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Genome Dynamics and Stability, |
| International Standard Serial Number |
1861-3373 ; |
| Volume/sequential designation |
140 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/b104871 |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
