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05509nam a22005295i 4500 |
| 001 - CONTROL NUMBER |
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978-0-387-74351-6 |
| 003 - CONTROL NUMBER IDENTIFIER |
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DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20161121230751.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr nn 008mamaa |
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100301s2008 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780387743516 |
| -- |
978-0-387-74351-6 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-0-387-74351-6 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RC321-580 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PSAN |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED057000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
612.8 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Cortical Deficits In Schizophrenia |
| Medium |
[electronic resource] : |
| Remainder of title |
From Genes to Function / |
| Statement of responsibility, etc. |
edited by Patricio O'Donnell. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Boston, MA : |
| Name of producer, publisher, distributor, manufacturer |
Springer US, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2008. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
XIII, 239 p. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Schizophrenia Genes: Searching for Common Features, Functions, and Mechanisms -- Towards a Molecular Classification of Illness: Effects of Schizophrenia Susceptibility Loci on Clinical Symptoms and Cognitive Function -- Homer: A Genetic Factor in Schizophrenia? -- Neuregulin-erbB Signaling and the Pathogenesis of Schizophrenia -- Nicotinic Cholinergic Cortical Dysfunction in Schizophrenia -- A Role for Glutamate Receptors, Transporters, and Interacting Proteins in Cortical Dysfunction in Schizophrenia -- Cortical Circuit Dysfunction in the NMDA Receptor Hypofunction Model for the Psychosis of Schizophrenia -- Alterations in Hippocampal Function in Schizophrenia: its Genetic Associations and Systems Implications -- Identifying Novel Target Genes in Psychotic Disorder Network Association Analyses -- Alterations in Cortical GABA Neurotransmission in Schizophrenia: Causes and Consequences -- Increased Cortical Excitability as a Critical Element in Schizophrenia Pathophysiology. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
The genetics of schizophrenia have taken the driver seat in the research related to this disorder in recent years. For a long time, it had been known that sharing genes with someone affected with schizophrenia conferred a 50% chance of acquiring the disease. Although this is fifty times the incidence in the normal population, it was evident that genes could not explain all factors involved. At best, one could think of a combination of gene traits conferring predisposition for the disease. Now, it is evident that although there are no genes that individually confer a strong liability, several candidate gene alleles do confer some risk, and perhaps a combination of genes could cause the emergence of symptoms in this multi-faceted psychiatric condition. As the research on predisposing genes soars, it is becoming clear that we need to be able to identify cellular processes the genes control and to provide patho-physiological scenarios that could link those cellular phenomena with symptoms. Cortical Deficits in Schizophrenia: From Genes to Function elaborates on that link. The contributions to this book reflect the current state of the connection between schizophrenia genetics and pathophysiology. The book opens with a chapter by Paul Harrison highlighting the several convergence points among the diverse schizophrenia-related genes. This is followed by chapters reviewing several different specific genes, including Neuregulin, DISC-1, dysbindin, and Homer, among others, and by several chapters presenting information on physiological cortical processes that could be affected by those genes. These include glutamatergic, GABAergic and cholinergic neurotransmission. Current hot topics in schizophrenia research are also highlighted in the book. A concept that is gaining strength in the field, for example, is the role of inhibitory neurotransmission in schizophrenia pathophysiology, with converging (and convincing) data from post-mortem and imaging studies. The possibility of deficits in cortical inhibition (causing the emergence of "noisy" cortical activity) is discussed throughout the book in relationship with possible alterations in GABA and/or glutamate activity in several cortical areas including the prefrontal cortex and the temporal lobe. Thus, the chapters in this book summarize the current state of affairs in schizophrenia pathophysiology, with a consideration of genetic elements that may contribute to it. Cortical Deficits in Schizophrenia: From Genes to Function will prove a useful tool for those interested in a better understanding of schizophrenia. Even if more predisposing genes (not included in this book) become identified, the work laid out here will prove critical for assigning a functional (or dysfunctional) role to those genes. Although this is a fast-evolving field, the information and concepts covered in this book will likely be useful for years to come. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Human genetics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Neurosciences. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Neurology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Psychiatry. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Neuropsychology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Cognitive psychology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Neurosciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Psychiatry. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Neurology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Human Genetics. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Neuropsychology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cognitive Psychology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
O'Donnell, Patricio. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
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| Relationship information |
Printed edition: |
| International Standard Book Number |
9780387743509 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-0-387-74351-6 |
| 912 ## - |
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ZDB-2-SBL |
