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06452nam a22005655i 4500 |
| 001 - CONTROL NUMBER |
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978-0-387-69057-5 |
| 003 - CONTROL NUMBER IDENTIFIER |
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DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20161121230748.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr nn 008mamaa |
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100301s2008 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780387690575 |
| -- |
978-0-387-69057-5 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-0-387-69057-5 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RC261-271 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MJCL |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED062000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
614.5999 |
| Edition number |
23 |
| 245 14 - TITLE STATEMENT |
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| Title |
The Cancer Degradome |
| Medium |
[electronic resource] : |
| Remainder of title |
Proteases and Cancer Biology / |
| Statement of responsibility, etc. |
edited by Dylan Edwards, Gunilla Høyer-Hansen, Francesco Blasi, Bonnie F. Sloane. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
New York, NY : |
| Name of producer, publisher, distributor, manufacturer |
Springer New York, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2008. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
XXIV, 926 p. 90 illus., 33 illus. in color. With 2 16-page inserts. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
The Degradome and Its Analysis -- Protease Genomics and the Cancer Degradome -- The CLIP-CHIP™: A Focused Oligonucleotide Microarray Platform for Transcriptome Analysis of the Complete Human and Murine Cancer Degradomes -- The Hu/Mu ProtIn Chip: A Custom Dual-Species Oligonucleotide Microarray for Profiling Degradome Gene Expression in Tumors and Their Microenvironment -- Quantitative Real-Time PCR Analysis of Degradome Gene Expression -- Identification of Protease Substrates by Mass Spectrometry Approaches-1 -- Identification of Protease Substrates by Mass Spectrometry Approaches-2 -- Activity-Based Imaging and Biochemical Profiling Tools for Analysis of the Cancer Degradome -- Images of Cleavage: Tumor Proteases in Action -- Insights into Protease Function -- Proteolytic Pathways: Intersecting Cascades in Cancer Development -- Physiological Functions of Plasminogen Activation: Effects of Gene Deficiencies in Humans and Mice -- The Plasminogen Activation System in Tissue Remodeling and Cancer Invasion -- The Urokinase Plasminogen Activator Receptor as a Target for Cancer Therapy -- The Endocytic Collagen Receptor, uPARAP/Endo180, in Cancer Invasion and Tissue Remodeling -- Physiological and Pathological Functions of Type II Transmembrane Serine Proteases: Lessons from Transgenic Mouse Models and Human Disease-Associated Mutations -- Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models -- In Vitro and In Vivo Models of Angiogenesis to Dissect MMP Functions -- The Surface Transplantation Model to Study the Tumor–Host Interface -- Unravelling the Roles of Proteinases in Cell Migration In Vitro and In Vivo -- New Insights into MMP function in Adipogenesis -- TIMPs: Extracellular Modifiers in Cancer Development -- The Interface Between Proteolysis and Cell Signalling -- Invadopodia: Interface for Invasion -- uPAR and Proteases in Mobilization of Hematopoietic Stem Cells -- The Urokinase Receptor and Integrins Constitute a Cell Migration Signalosome -- Measuring uPAR Dynamics in Live Cells -- Janus-Faced Effects of Broad-Spectrum and Specific MMP Inhibition on Metastasis -- Cytokine Substrates: MMP Regulation of Inflammatory Signaling Molecules -- Matrix Metalloproteinases as Key Regulators of Tumor–Bone Interaction -- The Degradome as Source of Cancer Diagnostic and Markers -- The Plasminogen Activation System as a Source of Prognostic Markers in Cancer -- Cysteine Cathepsins and Cystatins as Cancer Biomarkers -- Novel Degradome Markers in Breast Cancer -- Meta-Analysis of Gene Expression Microarray Data: Degradome Genes in Healthy and Cancer Tissues -- Degradome Gene Polymorphisms -- TIMP-1 as a Prognostic Marker in Colorectal Cancer -- Novel Therapeutic Strategies -- Structure and Inhibition of the Urokinase-Type Plasminogen Activator Receptor -- Engineered Antagonists of uPA and PAI-1 -- MMP Inhibitor Clinical Trials – The Past, Present, and Future -- Tailoring TIMPs for Selective Metalloproteinase Inhibition -- Third-Generation MMP Inhibitors: Recent Advances in the Development of Highly Selective Inhibitors -- Protease-Activated Delivery and Imaging Systems -- Development of Tumour-Selective and Endoprotease-Activated Anticancer Therapeutics -- Targeting Degradome Genes via Engineered Viral Vectors. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Proteases that act in the extracellular environment have been historically associated with tumorigenesis and metastasis by virtue of their ability to carry out "path-clearing" for cancer cells. In the past few years it has become clear that they also shape the pericellular signaling environment, with profound consequences for cell fate and phenotype in both normal development and disease states. The repertoire of proteases that cells and tissues coordinately regulate in order to modulate their local environment is the DEGRADOME – which in humans is represented by at least 569 proteases in five catalytic classes. "The Cancer Degradome: Proteases in Cancer Biology" , edited by Dylan Edwards, Francesco Blasi, Gunilla-Høyer-Hansen and Bonnie Sloane, covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how protease activity can be imaged both in vitro and in vivo; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; the links that have emerged between proteolysis and cell signaling; how the Degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to target proteolysis for therapy. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Cancer research. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Human genetics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Immunology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Medical microbiology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Molecular biology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Virology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Cancer Research. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Human Genetics. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Medical Microbiology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Immunology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Virology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Molecular Medicine. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Edwards, Dylan. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Høyer-Hansen, Gunilla. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Blasi, Francesco. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sloane, Bonnie F. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
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| Relationship information |
Printed edition: |
| International Standard Book Number |
9780387690568 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-0-387-69057-5 |
| 912 ## - |
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ZDB-2-SBL |
