| 000 -LEADER |
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| fixed length control field |
04224nam a22004575i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-3-540-46091-6 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20161121230741.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
100301s2007 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9783540460916 |
| -- |
978-3-540-46091-6 |
| 024 7# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.1007/978-3-540-46091-6 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
RC254-282 |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
MJCL |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
MED062000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
616.994 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Targeted Therapies in Cancer |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc. |
edited by Manfred Dietel. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Berlin, Heidelberg : |
| Name of producer, publisher, distributor, manufacturer |
Springer Berlin Heidelberg, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2007. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XIV, 262 p. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 490 1# - SERIES STATEMENT |
|---|
| Series statement |
Recent Results in Cancer Research, |
| International Standard Serial Number |
0080-0015 ; |
| Volume/sequential designation |
176 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Prediction of Tumor Behavior -- Beyond Typing and Grading: Target Analysis in Individualized Therapy as a New Challenge for Tumour Pathology -- Oncogenic Signaling Pathways and Deregulated Target Genes -- Predictive Pathology of Cytostatic Drug Resistance and New Anti-cancer Targets -- Prediction of Response to Neoadjuvant Chemotherapy in Carcinomas of the Upper Gastrointestinal Tract -- Resistance-Associated Signatures in Breast Cancer -- Resistance to Chemotherapy in Ovarian Carcinoma -- Clinical, Biological, and Molecular Aspects of Metastasis in Colorectal Cancer -- Prediction of Efficacy and Side Effects of Chemotherapy in Colorectal Cancer -- Proteomic Expression Profiling of Breast Cancer -- Targeted Therapy and Clinical Applications -- Targeted Therapy and Blood-Brain Barrier -- Cetuximab: Appraisal of a Novel Drug Against Colorectal Cancer -- C-kit, GIST, and Imatinib -- Antibody Therapy in Non-Hodgkin’s Lymphoma: The Role of Rituximab, 90Y-Ibritumomab Tiuxetan, and Alemtuzumab -- Molecular and Clinical Aspects of Proteasome Inhibition in the Treatment of Cancer -- Individualized Target Therapy of Malignant Lymphomas: An Outlook -- Antiangiogenesis, Anti-VEGF(R) and Outlook -- Morphological Detection of Hormone and Growth Factor Receptors in Breast Cancer -- Prospects for Development -- Antigen-Specific Cancer Vaccines -- Therapeutic Vaccination for the Treatment of Malignant Melanoma -- Monoclonal and Recombinant Antibodies with T Cell Receptor-Like Reactivity -- New Molecular Therapy Targets in Acute Myeloid Leukemia. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
From its introduction, oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients. This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing. Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy. This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cancer research. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Oncology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medicine & Public Health. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Oncology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cancer Research. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dietel, Manfred. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9783540460909 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Recent Results in Cancer Research, |
| International Standard Serial Number |
0080-0015 ; |
| Volume/sequential designation |
176 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-3-540-46091-6 |
| 912 ## - |
|---|
| -- |
ZDB-2-SME |
