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05177nam a22004815i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-0-387-47530-1 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20161121230733.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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100301s2007 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780387475301 |
| -- |
978-0-387-47530-1 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-0-387-47530-1 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RC681-688.2 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MJD |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED010000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
616.12 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Molecular Sensors for Cardiovascular Homeostasis |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc. |
edited by Donna H. Wang. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Boston, MA : |
| Name of producer, publisher, distributor, manufacturer |
Springer US, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2007. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
VIII, 212 p. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
The DEG/ENaC Family -- The Role of DEG/ENaC Ion Channels in Sensory Mechanotransduction -- ASICs Function as Cardiac Lactic Acid Sensors During Myocardial Ischemia -- Molecular Components of Neural Sensory Transduction -- The TRP Family -- TRP Channels as Molecular Sensors of Physical Stimuli in the Cardiovascular System -- TRPV1 in Central Cardiovascular Control -- TRPV1 as a Molecular Transducer for Salt and Water Homeostasis -- Functional Interaction Between ATP and TRPV1 Receptors -- TRPV4 and Hypotonic Stress -- Other Ion Channels and Biosensors -- Ion Channels in Shear Stress Sensing in Vascular Endothelium -- Redox Signaling in Oxygen Sensing by Vessels -- Impedance Spectroscopy and Quartz Crystal Microbalance. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Molecular Sensors for Cardiovascular Homeostasis Donna H. Wang, MD, FAHA, FAAN Biological homeostasis is maintained via intact function of an array of molecules detecting changes of microenvironments inside and outside of the biological system. These molecules including cell membrane proteins and ion channels are intimately involved in a variety of sensory pathways and respond to environmental stimuli, including altered temperature, pH, mechanical and osmotic stress, intra- and extracellular messengers, as well as changes in energy consumption. All of these modalities are involved in systemic, cellular, and molecular regulation. A better understanding of the structural, functional, and physiological properties of these proteins/ion channels would provide insight into mechanisms underlying disease processes, as well as facilitate fabrication of precisely defined, nanostructured interfacial architectures or molecular electronics that express and measure the activities of these proteins/channels. Molecular Sensors for Cardiovascular Homeostasis reveals state-of-the-science of several newly discovered ion channel families and their role in the pathogenesis of cardiovascular diseases. This work offers comprehensive and up-to-date information for a deeper understanding of the relationship between macro- and micro-environments, ion channels, and pathophysiological responses, and for developing novel therapies for treating devastating cardiovascular illnesses. Molecular Sensors for Cardiovascular Homeostasis is essential reading for neuroscientists, molecular biologists, cardiovascular researchers, electrophysiologists, cardiologists, pathologists, neurosurgeons, and researchers and students interested in biomedical engineering, nanotechnology, and design and development of medical devices. Key Topics: Degenerin Ion Channel Family Transient Receptor Potential Ion Channel Family Ion Channels in Mechanotransduction Redox Signaling in Oxygen Sensing Molecular Electronics as Biosensors Neural Sensory Transduction Baro- and Chemo-Receptors Cardiac lactic Acid Sensors Central Cardiovascular Control Salt and Water Homeostasis Osmotic Sensing Ligand-Receptor Interfacing About the Editor: Dr. Donna H. Wang is a Professor in the Department of Medicine, Neuroscience Program, and Cell & Molecular Biology Program at Michigan State University. She also serves as the Director of Investigative Medicine and the Vice Chair for Basic Research for the Department of Medicine. Dr. Wang is an Established Investigator of the American Heart Association, a Fellow of the American Heart Association Council for High Blood Pressure Research, a Fellow of Cardiovascular Section of the American Physiological Society, and a Fellow of the American Academy of Nanomedicine. She serves on many national and international scientific and policy review panels and committees, including US National Institutes of Health, American Heart Association, and the Wellcome Trust of UK. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Human genetics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Molecular biology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Cardiology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Biomedical engineering. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Medicine & Public Health. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Cardiology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Biomedical Engineering. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Human Genetics. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Molecular Medicine. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wang, Donna H. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9780387475288 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
http://dx.doi.org/10.1007/978-0-387-47530-1 |
| 912 ## - |
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| -- |
ZDB-2-SME |
