000 -LEADER |
fixed length control field |
03965nam a22004215i 4500 |
001 - CONTROL NUMBER |
control field |
978-1-59259-931-8 |
003 - CONTROL NUMBER IDENTIFIER |
control field |
DE-He213 |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20161121230702.0 |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
fixed length control field |
cr nn 008mamaa |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
100301s2006 xxu| s |||| 0|eng d |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
9781592599318 |
-- |
978-1-59259-931-8 |
024 7# - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1385/1592599311 |
Source of number or code |
doi |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
Classification number |
RS1-441 |
072 #7 - SUBJECT CATEGORY CODE |
Subject category code |
MQP |
Source |
bicssc |
072 #7 - SUBJECT CATEGORY CODE |
Subject category code |
MED072000 |
Source |
bisacsh |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
615.1 |
Edition number |
23 |
245 14 - TITLE STATEMENT |
Title |
The Adrenergic Receptors |
Medium |
[electronic resource] : |
Remainder of title |
In the 21st Century / |
Statement of responsibility, etc. |
edited by Dianne M. Perez. |
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
Place of production, publication, distribution, manufacture |
Totowa, NJ : |
Name of producer, publisher, distributor, manufacturer |
Humana Press, |
Date of production, publication, distribution, manufacture, or copyright notice |
2006. |
300 ## - PHYSICAL DESCRIPTION |
Extent |
XII, 404 p. |
Other physical details |
online resource. |
336 ## - CONTENT TYPE |
Content type term |
text |
Content type code |
txt |
Source |
rdacontent |
337 ## - MEDIA TYPE |
Media type term |
computer |
Media type code |
c |
Source |
rdamedia |
338 ## - CARRIER TYPE |
Carrier type term |
online resource |
Carrier type code |
cr |
Source |
rdacarrier |
347 ## - DIGITAL FILE CHARACTERISTICS |
File type |
text file |
Encoding format |
PDF |
Source |
rda |
490 1# - SERIES STATEMENT |
Series statement |
The Receptors |
505 0# - FORMATTED CONTENTS NOTE |
Formatted contents note |
Historical Perspectives -- Adrenergic Receptors -- Structure-Function -- Ligand Binding, Activation, and Agonist Trafficking -- New Signal Transduction Paradigms -- Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors -- Adrenergic Receptors in Clinical Medicine -- Imaging Adrenergic Receptors and Their Function -- Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors -- Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors -- Genetically Altered Mouse Models -- The ?1-Adrenergic Receptors -- The ?2-Adrenergic Receptors -- The ?-Adrenergic Receptors -- Lessons From Overexpressed Mouse Models -- Adrenergic Receptor Signaling Components in Gene Therapy -- Pharmacogenomics -- Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms -- Microarray Analysis of Novel Adrenergic Receptor Functions -- Summary and Future Endeavors -- Summary and Future Endeavors. |
520 ## - SUMMARY, ETC. |
Summary, etc. |
The adrenergic receptors control many critical functions of the heart, kidney, brain, and all organs under autonomic control. Today significant opportunities exist for molecular and genetic analysis of their function and signaling pathways. In The Adrenergic Receptors: In the 21st Century, senior scientists who have developed novel molecular approaches describe the state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Many of the methods described can be applied to characterize any receptor of interest. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on both clinical outcomes and potential gene therapy applications. Additional chapters address modern techniques for assessing adrenergic function, such as fluorescent labeling and microarrays, and offer an insightful historical survey of the extraordinary progress made in our understanding of these receptors in the twentieth century. Comprehensive and authoritative, The Adrenergic Receptors: In the 21st Century provides researchers-through its side-by-side comparison of all the adrenergic receptors (a1, a2, and b) and their subtypes-with an excellent survey of the field, including the rationale for how best to design better drugs for control of the heart, blood pressure, and related pathophysiological systems. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Pharmacy. |
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Pharmacy. |
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Pharmacy. |
700 1# - ADDED ENTRY--PERSONAL NAME |
Personal name |
Perez, Dianne M. |
Relator term |
editor. |
710 2# - ADDED ENTRY--CORPORATE NAME |
Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
773 0# - HOST ITEM ENTRY |
Title |
Springer eBooks |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
Relationship information |
Printed edition: |
International Standard Book Number |
9781588294234 |
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
Uniform title |
The Receptors |
856 40 - ELECTRONIC LOCATION AND ACCESS |
Uniform Resource Identifier |
http://dx.doi.org/10.1385/1592599311 |
912 ## - |
-- |
ZDB-2-SBL |