| 000 -LEADER |
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| fixed length control field |
04275nam a22005535i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-1-4020-4709-1 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20161121230700.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
100301s2006 ne | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9781402047091 |
| -- |
978-1-4020-4709-1 |
| 024 7# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.1007/1-4020-4709-6 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QH301-705 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PSA |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
SCI086000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
570 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Smad Signal Transduction |
| Medium |
[electronic resource] : |
| Remainder of title |
Smads in Proliferation, Differentiation and Disease / |
| Statement of responsibility, etc. |
edited by Peter ten Dijke, Carl-Henrik Heldin. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Dordrecht : |
| Name of producer, publisher, distributor, manufacturer |
Springer Netherlands, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2006. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XIV, 472 p. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 490 1# - SERIES STATEMENT |
|---|
| Series statement |
Proteins and Cell Regulation ; |
| Volume/sequential designation |
5 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Molecular Evolution of Smad Proteins -- C. Elegans TGF-? Signaling Pathways -- Smads In Drosophila – Interpretation Of Graded Signals In Vivo -- Delineating the TGF-?/Smad-Induced Cytostatic Response -- Smads In Mesenchymal Differentiation -- Smad Proteins in Apoptotic and Survival Signaling -- TGF-?/SMAD Signaling in Epithelial to Mesenchymal Transition -- Genetic Disruptions within the Murine Genome Reveal Numerous Roles of the Smad Gene Family in Development, Disease, and Cancer -- Trafficking of Serine/Threonine Kinase Receptors and Smad Activation -- Nucleocytoplasmic Shuttling of Smad Proteins -- Structural Insights into Smad Function and Specificity -- Regulation of Smad Function by Phosphorylation -- Regulation of Smad Functions Through Ubiquitination and Sumoylation Pathways -- Smad Transcriptional Co-Activators and Co-Repressors -- Integration of Signaling Pathways Via Smad Proteins -- Interplays Between The Smad and Map Kinase Signaling Pathways -- Gene Expression Signatures of TGF-?/Smad-Induced Responses -- Systems Biology Approaches to TGF-?/Smad Signaling -- Inhibitory Smads: Mechanisms of Action and Roles in Human Diseases -- Alterations in Smad Signaling in Carcinogenesis -- TGF-? Receptor Kinase Inhibitors for the Treatment of Cancer -- TGF-? Receptor Kinase Inhibitors for Treatment of Fibrosis. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
For the first time world-leading experts in the area of cellular signaling have joined to the production of a book on Smad signal transduction. Smads are the principal intracellular effectors of TGF-b family members that control numerous cellular responses with critical roles in development and in tissue homeostasis. In a series of 22 cutting-edge chapters forward looking reviews of Smads are provided that cover their discovery, evolution, role in development, mechanism of action and regulation, and how deregulation in Smad signalling contributes to human diseases. Written for an audience with basic understanding of molecular and cell biology, this volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided. This book will be of particular interest to basic and applied biomedical researchers (students, post-docs or group leaders) with desire to understand the principles of cell-cell communication and mechanisms by which signaling pathways and gene programs control cell proliferation and differentiation, and how this knowledge may come to be applied in the clinic. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Life sciences. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cancer research. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Molecular biology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Biochemistry. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cell biology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Developmental biology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Life Sciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Life Sciences, general. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Molecular Medicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cancer Research. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Biochemistry, general. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cell Biology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Developmental Biology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dijke, Peter ten. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Heldin, Carl-Henrik. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9781402045424 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Proteins and Cell Regulation ; |
| Volume/sequential designation |
5 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/1-4020-4709-6 |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
