| 000 -LEADER |
|---|
| fixed length control field |
04922nam a22005055i 4500 |
| 001 - CONTROL NUMBER |
|---|
| control field |
978-1-4020-4142-6 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20161121230658.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
|---|
| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
100301s2005 ne | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9781402041426 |
| -- |
978-1-4020-4142-6 |
| 024 7# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.1007/1-4020-4142-X |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
R-RZ |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
MBGR |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
MED000000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
610 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Drug Metabolism |
| Medium |
[electronic resource] : |
| Remainder of title |
Current Concepts / |
| Statement of responsibility, etc. |
edited by Corina Ionescu, Mino R. Caira. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Dordrecht : |
| Name of producer, publisher, distributor, manufacturer |
Springer Netherlands, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2005. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XIV, 422 p. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Drug Metabolism In Context: Introduction -- Absorption -- Drug Distribution -- Dynamics Of Drug Action -- Drug Clearance -- Dynamics Of Drug Clearance -- Pathways Of Biotransformation – Phase I Reactions: Introduction -- Phase I And Phase Ii Metabolism: General Considerations -- Oxidations Involving The Microsomal Mixed-Function Oxidase System -- Oxidations Involving Other Enzymatic Systems -- Metabolic Reactions Involving Reduction -- Hydrolysis -- Miscellanous Phase I Reactions -- The Fate Of Phase I Reaction Products -- . Pathways Of Biotransformation – Phase I Reactions: Introduction -- Glucuronidation -- Acetylation -- Glutathione Conjugation -- Other Conjugative Reactions -- Concluding Remarks -- Enzymatic Systems Involved In Drug Biotransformation: Ntroduction -- Interaction Between A Drug Substrate And An Enzyme -- Enzyme Systems With Specific Roles -- Final Remarks -- Induction And Inhibition Of Drug-Metabolising Enzymes -- Introduction -- Induction -- Inhibition -- Consequences Of The Above Phenomena -- Dietary And Non-Dietary Factors In Enzyme Induction And Inhibition -- Factors That Influence Drug Biotransformation -- Introduction -- Intrinsic Factors -- Environmental Factors -- Further Observations -- Impact Of Gene Variability On Drug Metabolism -- Introduction -- Basic Principles Of Pharmacogenetics -- Pharmaco-Informatics -- Implications For Third Millennium Medicine -- Drug Interactions And Adverse Reactions: Introduction -- Drug-Drug Interactions -- Interactions Between Drugs And Other Entities -- Adverse Reactions -- Summary -- Strategies For Drug Design -- Introduction -- Pharmacokinetics And Metabolism In Drug Research -- The Role Of Formulation -- Concluding Remarks -- Index. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Drug Metabolism: Current Concepts Corina Ionescu and Mino R Caira Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. The book includes chapters on ADME (drug absorption, distribution, metabolism and elimination) Pathways of biotransformation (Phase I and Phase II metabolic reactions) Enzymatic systems involved in biotransformation Induction and inhibition of drug-metabolising enzymes Factors that influence drug biotransformation The role of pharmacogenetics Drug-drug interactions and adverse reactions Strategies for drug design. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Pharmacy. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Molecular biology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Pharmacology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medicinal chemistry. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Biomedicine general. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Pharmacy. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medicinal Chemistry. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Pharmacology/Toxicology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Molecular Medicine. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ionescu, Corina. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Caira, Mino R. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9781402041419 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/1-4020-4142-X |
| 912 ## - |
|---|
| -- |
ZDB-2-SBL |
