| 000 -LEADER |
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03625nam a22005055i 4500 |
| 001 - CONTROL NUMBER |
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978-0-387-27530-7 |
| 003 - CONTROL NUMBER IDENTIFIER |
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DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20161121230649.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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100301s2005 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780387275307 |
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978-0-387-27530-7 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/0-387-27530-4 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QH506 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MBGR |
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bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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PSD |
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bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
SCI049000 |
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bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED067000 |
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bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
611.01816 |
| Edition number |
23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Naveh-Many, Tally. |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
Molecular Biology of the Parathyroid |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc. |
by Tally Naveh-Many. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
Boston, MA : |
| Name of producer, publisher, distributor, manufacturer |
Springer US, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2005. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
XIV, 199 p. 71 illus., 5 illus. in color. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
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rdacontent |
| 337 ## - MEDIA TYPE |
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computer |
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c |
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rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 490 1# - SERIES STATEMENT |
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| Series statement |
Molecular Biology Intelligence Unit |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Development of Parathyroid Glands -- Parathyroid Hormone, from Gene to Protein -- Toward an Understanding of Human Parathyroid Hormone Structure and Function -- The Calcium Sensing Receptor -- Regulation of Parathyroid Hormone mRNA Stability by Calcium and Phosphate -- In Silico Analysis of Regulatory Sequences in the Human Parathyroid Hormone Gene -- Regulation of Parathyroid Hormone Gene Expression by 1,25-Dihydroxyvitamin D -- Vitamin D Analogs for the Treatment of Secondary Hyperparathyroidism in Chronic Renal Failure -- Parathyroid Gland Hyperplasia in Renal Failure -- Molecular Mechanisms in Parathyroid Tumorigenesis -- Molecular Genetic Abnormalities in Sporadic Hyperparathyroidism -- Genetic Causes of Hypoparathyroidism -- Skeletal and Reproductive Abnormalities in Pth-Null Mice. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
aintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu� M lar calcium levels, by acting on bone, kidney and intestine. The recent intro� duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper� plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres� sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha� nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para� thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex� pression to its intracellular processing and the sequences in the gene control� ling its transcription as well as those regulating mRNA processing, stability and translation are described. 0 |
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Medi |
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Mole |
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Endo |
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Neph |
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Biom |
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Mole |
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Neph |
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Endo |
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Spri |
| 710 ## - ADDED ENTRY--CORPORATE NAME |
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| Title of a work |
Spri |
| 773 ## - HOST ITEM ENTRY |
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| Relationship information |
Prin |
| 776 ## - ADDITIONAL PHYSICAL FORM ENTRY |
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| International Standard Book Number |
9780306478475 0 |
| Main entry heading |
Mole |
| 830 ## - SERIES ADDED ENTRY--UNIFORM TITLE |
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http |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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ZDB- |
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Biom |
