| 000 -LEADER |
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04940nam a22004695i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-0-387-25446-3 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20161121230648.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
100301s2005 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780387254463 |
| -- |
978-0-387-25446-3 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/b107412 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RC321-580 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PSAN |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED057000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
612.8 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Hypocretins |
| Medium |
[electronic resource] : |
| Remainder of title |
Integrators of Physiological Functions / |
| Statement of responsibility, etc. |
edited by Luis de Lecea, J. Gregor Sutcliffe. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
Boston, MA : |
| Name of producer, publisher, distributor, manufacturer |
Springer US, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2005. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
XXIV, 441 p. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Discovery of the Hypocretins/Orexins and Their Receptors -- The Discovery of the Hypocretins -- Orexin and Orexin Receptors -- Animal Models in the Study of the Hypocretinergic System -- Rodent Models of Human Narcolepsy-cataplexy -- The Canine Model of Narcolepsy -- Detailed Anatomy of the Hypocretinergic System and Related Hypothalamic Circuits -- Anatomy of the Hypocretin System -- The Anatomy of Hypocretin Neurons -- Transmitter-Identified Neurons and Afferent Innervation of the Lateral Hypothalamic Area -- Physiological Consequences of Hypocretin Activation -- Physiological Characteristics of Hypocretin/Orexin Neurons -- The Ne System as a Target for Hypocretin Neurons -- Hypocretin/Orexin Actions on Mesopontine Cholinergic Systems Controling Behavioral State -- The Aminergic Systems and the Hypocretins -- Effects Of Hypocretin/Orexin on the Thalamocortical Activating System -- Pharmacology of the Hypocretins and Drug Design -- In Vivo Pharmacology of Orexin (Hypocretin) Receptors -- Intracellular Signal Pathways Utilized by the Hypocretin/Orexin Receptors -- The Hypocretins in Narcolepsy and Arousal -- The Hypocretins and Narcolepsy -- An Approach to Determining the Functions of Hypocretin (Orexin) -- Hypocretin in Neuropsychiatric Disorders -- Hypocretin/Orexin and Sleep -- Modulation of Cortical Activity and Sleep-Wake States by Hypocretin/Orexin -- The Hypocretins in Feeding and Energy Balance -- Regulation of Hypocretin by Metabolic Signals -- The Hypocretins in Addiction and Hyperarousal -- Hypocretin and Brain Reward Function -- Orexin/Hypocretin and Opioid Dependence -- Dopamine-Hypocretin/Orexin Interactions -- Hypocretin/Orexin in Stress and Arousal -- Role of Hypocretins on Peripheral Systems -- The Hypocretins/Orexins and the Hypothalamo-Pituitary-Adrenal Axis -- Orexins (Hypocretins) in the Gut -- Hypocretins in Endocrine Regulation -- The Hypocretins in Cardiovascular Regulation. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Neurosciences. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Endocrinology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Neurology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Neurosciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Endocrinology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Neurology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Lecea, Luis de. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sutcliffe, J. Gregor. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
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| Relationship information |
Printed edition: |
| International Standard Book Number |
9780387250007 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
http://dx.doi.org/10.1007/b107412 |
| 912 ## - |
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| -- |
ZDB-2-SBL |
