| 000 -LEADER |
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| fixed length control field |
04160nam a22005535i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-1-4020-4483-0 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20161121230637.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
100301s2006 ne | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9781402044830 |
| -- |
978-1-4020-4483-0 |
| 024 7# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.1007/1-4020-4483-6 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
RC799-869 |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
MJH |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
MED031000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
616.33 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Proteases in Gastrointestinal Tissues |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc. |
edited by Uwe Lendeckel, Nigel M. Hooper. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Dordrecht : |
| Name of producer, publisher, distributor, manufacturer |
Springer Netherlands, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2006. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XVIII, 344 p. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 490 1# - SERIES STATEMENT |
|---|
| Series statement |
Proteases in Biology and Disease, |
| International Standard Serial Number |
0952-0042 ; |
| Volume/sequential designation |
5 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Protease-Activated Receptors in Gastrointestinal Function and Disease -- Matrix Metalloproteinases in Gastric Cancer -- Proteases in Helicobacter pylori-Mediated Diseases -- Proteases in Pancreatic Disease -- PAR in the Pathogenesis of Pain in Pancreatic Disease -- Importance of the Local Renin-Angiotensin System in Pancreatic Disease -- Hepatitis C Viral Proteases And Inhibitors -- Angiotensin Converting Enzyme in the Pathophysiology of Liver Fibrosis -- Matrix Metalloproteinases in Chronic Liver Disease and Liver Transplantation -- MMPs and ADAMs in Inflammatory Bowel Disease -- Chemokines and Matrix Metalloproteinases in Colorectal Cancer -- Angiotensin-Converting Enzyme (ACE) in Gut Inflammation -- Intestinal Apical Protein Transport in Health and Disease. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
This, the fifth volume in the Proteases in Biology and Disease series, is devoted to Proteases in Gastrointestinal Tissues. Of course, proteases play an important role in the digestion and utilization of ingested proteins, but besides that they elicit a wide range of physiological and pathological effects. Proteases have been recognized as essential regulators, acting both locally and systemically, of normal development, growth and functioning. Dysregulation of protease expression and/or enzymatic activity is often associated with the onset or progression of disease and, thus, proteases represent interesting targets for the pharmacological therapy of e. g. cancer, chronic inflammation, graft rejection, fibrosis, diabetes, vascular disease, and viral or bacterial infections. In addition, changes in the localization, abundance or activity of proteases may serve as informative diagnostic or prognostic markers. This volume focuses on stomach, gut, pancreas, and liver and highlights the role of proteases in normal physiology and disease processes involving these tissues. The first chapter by Nigel W. Bunnett and Graeme S. Cottrell reviews the current knowledge about the protease-activated receptors (PARs) in gastrointestinal tissues. Starting with the mechanisms of activation, signal transduction, and regulation of PAR, their role in controlling gastrointestinal functions and the possible involvement in gastrointestinal diseases are summarized. In Chapter 2, Nikhil I. Khushalani and Nithya Ramnath review the role of matrix metalloproteases (MMPs) and their natural inhibitors, TIMPs, in different types of gastric cancer. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cancer research. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Pharmacology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Internal medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Gastroenterology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Hepatology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medicine & Public Health. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Gastroenterology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Biomedicine general. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Hepatology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cancer Research. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Internal Medicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Pharmacology/Toxicology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Lendeckel, Uwe. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hooper, Nigel M. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9781402044823 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Proteases in Biology and Disease, |
| International Standard Serial Number |
0952-0042 ; |
| Volume/sequential designation |
5 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/1-4020-4483-6 |
| 912 ## - |
|---|
| -- |
ZDB-2-SME |
