| 000 -LEADER |
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04233nam a22005535i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-3-7643-7379-5 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20161121230601.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
100301s2005 sz | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783764373795 |
| -- |
978-3-7643-7379-5 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/3-7643-7379-2 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RB127 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RD78.3-87.3 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MMBP |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED093000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
616.0472 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc. |
edited by Annika B. Malmberg, Keith R. Bley. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Basel : |
| Name of producer, publisher, distributor, manufacturer |
Birkh�user Basel, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2005. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XII, 249 p. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| File type |
text file |
| Encoding format |
PDF |
| Source |
rda1 |
| 490 ## - SERIES STATEMENT |
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| Series statement |
Progress in Inflammation Research0 |
| 505 ## - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Historical perspective on capsaicin and its receptor -- Hot peppers, pain and analgesics -- Molecular and cellular properties of vanilloid receptors -- Structural determinants of TRPV1 functionality -- TRPV1 distribution and regulation -- Pharmacology and physiology of vanilloid receptors -- Insights into TRPV1 pharmacology provided by non-capsaicin ligands -- Endocannabinoids and vanilloid TRPV1 receptors -- Vanilloid receptor-mediated hyperalgesia and desensitization -- Capsaicin in human experimental pain models of skin, muscle and visceral sensitization -- Vanilloid receptor involvement in disease states -- TRPV1 in gut function, abdominal pain and functional bowel disorders -- TRPV1 in the airways -- Therapeutic potential of vanilloid agonists and antagonists -- TRPV1 agonist-based therapies: mechanism of action and clinical prospects -- TRPV1 agonist therapies in bladder diseases -- TRPV1 antagonists and chronic pain. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appeared in 1850 [1]. However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were. Despite widespread use, it was not until 1878 that the selective action of capsaicin on the sensory nervous system was r- ognized [2]. In Chapter 1 of this volume, Janos Szolcs�nyi reviews this early research, which culminated with the seminal studies of Nicholas Jansco and his c- leagues in Hungary in the 1940s. Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema. 0 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Medicine. 0 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Immunology. 0 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Neurosciences. 0 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Pharmacology. 0 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Pain medicine. 0 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Cell biology.14 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Medicine & Public Health.24 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Pain Medicine.24 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Immunology.24 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Neurosciences.24 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Pharmacology/Toxicology.24 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Cell Biology.1 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Malmberg, Annika B. |
| Relator term |
editor.1 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Bley, Keith R. |
| Relator term |
editor.2 |
| 710 ## - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service)0 |
| 773 ## - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks08 |
| 776 ## - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9783764370800 0 |
| 830 ## - SERIES ADDED ENTRY--UNIFORM TITLE |
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| Uniform title |
Progress in Inflammation Research40 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
http://dx.doi.org/10.1007/3-7643-7379-2 |
| 912 ## - |
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| -- |
ZDB-2-SME |
