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Molecular Neurosurgery With Targeted Toxins (Record no. 500775)

000 -LEADER
fixed length control field 03802nam a22004215i 4500
001 - CONTROL NUMBER
control field 978-1-59259-896-0
003 - CONTROL NUMBER IDENTIFIER
control field DE-He213
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20161121230555.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 100301s2005 xxu| s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781592598960
-- 978-1-59259-896-0
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1007/978-1-59259-896-0
Source of number or code doi
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RD592.5-596
072 #7 - SUBJECT CATEGORY CODE
Subject category code MNN
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED085010
Source bisacsh
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 617.48
Edition number 23
245 10 - TITLE STATEMENT
Title Molecular Neurosurgery With Targeted Toxins
Medium [electronic resource] /
Statement of responsibility, etc. edited by Ronald G. Wiley, Douglas A. Lappi.
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Totowa, NJ :
Name of producer, publisher, distributor, manufacturer Humana Press,
Date of production, publication, distribution, manufacture, or copyright notice 2005.
300 ## - PHYSICAL DESCRIPTION
Extent XII, 312 p.
Other physical details online resource.
336 ## - CONTENT TYPE
Content type term text
Content type code txt
Source rdacontent
337 ## - MEDIA TYPE
Media type term computer
Media type code c
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term online resource
Carrier type code cr
Source rdacarrier
347 ## - DIGITAL FILE CHARACTERISTICS
File type text file
Encoding format PDF
Source rda
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note to Molecular Neurosurgery -- Ribosome-Inactivating Proteins -- Biochemical, Physiological, and Behavioral Characterizations of the Cholinergic Basal Forebrain Lesion Produced by 192 IgG-Saporin -- Basal Forebrain Cholinergic Lesion by 192 IgG-Saporin -- 192 IgG-Saporin-Induced Partial Cortical Cholinergic Deafferentation as a Model for Determining the Interactions Between Brain Aging and Neurodevelopmental Defects in the Cortical Cholinergic Input System -- Exploring the Role of Acetylcholine in Primate Cognition Using Me20.4 IgG-Saporin -- Cortical Cholinergic Deafferentation Induces A? Deposition -- Chemical Dissection of Brain Glucoregulatory Circuitry -- Cardiovascular Deficits After Lesions of C1 Adrenergic Neurons With a Saporin-Based Immunotoxin -- Saporin Conjugates and Pain -- The Use of Saporin Conjugates to Dissect Neurons Responsible for Sleep and Wakefulness -- Isolectin IB4-Mediated Cytotoxic Targeting of Sensory Neurons -- B Fragment of Cholera Toxin Conjugated to Saporin.
520 ## - SUMMARY, ETC.
Summary, etc. The use of targeted cytotoxins to make highly selective neural lesions for both experimental and clinical purposes has already provided important animal models for diseases such as Alzheimer's, and holds great promise for research and clinical application to pain. In Molecular Neurosurgery With Targeted Toxins, pioneers in the field describe their hands-on experience with the experimental use of these toxins. The authors focus on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents. Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Medicine.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Neurosurgery.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Medicine & Public Health.
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Neurosurgery.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Wiley, Ronald G.
Relator term editor.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lappi, Douglas A.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Relationship information Printed edition:
International Standard Book Number 9781588291998
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1007/978-1-59259-896-0
912 ## -
-- ZDB-2-SME
Holdings
Withdrawn status Lost status Damaged status Not for loan Permanent Location Current Location Date acquired Barcode Date last seen Price effective from Koha item type
        PK Kelkar Library, IIT Kanpur PK Kelkar Library, IIT Kanpur 2016-11-21 EBK1062 2016-11-21 2016-11-21 E books

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