| 000 -LEADER |
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| fixed length control field |
04817nam a22004455i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-0-387-23188-4 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20161121230551.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
100301s2005 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780387231884 |
| -- |
978-0-387-23188-4 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/b100805 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RC681-688.2 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MJD |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
MED010000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
616.12 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Ryanodine Receptors |
| Medium |
[electronic resource] : |
| Remainder of title |
Structure, function and dysfunction in clinical disease / |
| Statement of responsibility, etc. |
edited by Xander H. T. Wehrens, Andrew R. Marks. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Boston, MA : |
| Name of producer, publisher, distributor, manufacturer |
Springer US, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2005. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XXI, 330 p. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 490 1# - SERIES STATEMENT |
|---|
| Series statement |
Developments in Cardiovascular Medicine, |
| International Standard Serial Number |
0166-9842 ; |
| Volume/sequential designation |
254 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Evolution of the Ryanodine Receptor Gene Family -- Topology and Transmembrane Organization of Ryanodine Receptors -- Three-Dimensional Reconstruction of Ryanodine Receptors -- RYR-DHPR Relationships in Skeletal and Cardiac Muscles -- The Pore of the Ryanodine Receptor Channel -- Intra-Molecular Domain-Domain Interaction -- Regulation of Sarcoplasmic Reticulum Calcium Release by Luminal Calcium -- Cytosolic Calcium Regulation of Single Ryanodine Receptor Channels -- Elementary Ca2+ Release Events: Ryanodine Receptor Ca2+ Sparks -- Ca2+ Release from the Sarcoplasmic Reticulum in Intact Cardiomyocytes -- Stability and Instability of Ca2+ Release from the SR -- Ryanodine Receptors in Smooth Muscle -- Functions of RYR3 Homologues -- Knockout Mice Lacking RYR and Junctophilin Subtypes -- Regulation of Ryanodine Receptor Ca2+ Release by Macromolecular Complexes -- RYR1 Modulation by Calmodulin -- Ryanodine Receptor Function in Inflammation -- Ryanoids, Receptor Affinity and RYR Channel Subconductance -- Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function -- Redox Sensing by the Ryanodine Receptors -- Ryanodine Receptor Dysfunction in the Diabetic Heart -- Molecular and Clinical Genetics of RYR1 Disorders -- Pathophysiology of Muscle Disorders Linked to Mutations in the Skeletal Muscle Ryanodine Receptor -- The Dantrolene Binding Site on RYR1 -- Ryanodine Receptor Dysfunction in Heart Failure and Arrhythmias -- Stabilization of Ryanodine Receptor as a Novel Therapeutic Strategy Against Heart Failure -- Ryanodine Receptor Antibodies and Myasthenia Gravis. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
In recent years, the ryanodine receptor has emerged as a new and very promising target for the treatment of several cardiovascular disorders, including cardiac arrhythmias and heart failure. This volume is the most current publication devoted to the major intracellular calcium-release channel, the ryanodine receptor. "In this series of brief but informative chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology." David E. Clapham, MD, PhD Professor of Neurobiology and Pediatrics Harvard Medical School Dr. Xander H.T. Wehrens received his M.D. and Ph.D. degrees from Maastricht University in the Netherlands. His research has mainly concentrated on molecular mechanisms of cardiac arrhythmias, in particular in the setting of inherited arrhythmogenic syndromes and congestive heart failure. This work has led to the development of novel anti-arrhythmic therapies. He is currently a research scientist in the Department of Physiology and Cellular Biophysics at the College of Physicians and Surgeons of Columbia University. Dr. Andrew R. Marks is the Chair and Professor of the Department of Physiology and Cellular Biophysics at Columbia University College of Physicians and Surgeons. Dr. Marks' research has focused on understanding how macromolecular signaling complexes regulate ion channel function in muscle and non-muscle systems, and on the regulation of vascular smooth muscle proliferation and migration. His work has contributed new understandings of fundamental mechanisms that regulate muscle contraction that have lead to the discovery of molecular defects that contribute to heart failure and fatal cardiac arrhythmias. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cardiology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medicine & Public Health. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cardiology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Wehrens, Xander H. T. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Marks, Andrew R. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9780387231877 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Developments in Cardiovascular Medicine, |
| International Standard Serial Number |
0166-9842 ; |
| Volume/sequential designation |
254 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://dx.doi.org/10.1007/b100805 |
| 912 ## - |
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| -- |
ZDB-2-SME |
